ALC-0159
ALC-0159 is a lipid nanoparticle used in the formulation of the Pfizer–BioNTech COVID-19 vaccine, also known as BNT162b2. It is one of the four lipids in the vaccine that encapsulate the mRNA (messenger RNA) to protect it from degradation and help it enter cells.
Composition
ALC-0159 is a polyethylene glycol (PEG)-lipid conjugate. The PEG-lipid conjugate is used to increase the stability of the lipid nanoparticle and prolong the circulation time of the mRNA in the body. The PEG-lipid conjugate consists of two parts: a lipid anchor and a PEG chain. The lipid anchor is a phospholipid that can insert into the lipid nanoparticle, while the PEG chain extends out from the surface of the nanoparticle.
Role in Pfizer–BioNTech COVID-19 Vaccine
In the Pfizer–BioNTech COVID-19 vaccine, ALC-0159 forms part of the lipid nanoparticle that encapsulates the mRNA encoding the SARS-CoV-2 spike protein. The lipid nanoparticle protects the mRNA from degradation in the body and helps it enter cells. Once inside a cell, the mRNA is released and used as a template to produce the spike protein, which triggers an immune response.
Safety
The safety of ALC-0159 is supported by data from preclinical and clinical studies of the Pfizer–BioNTech COVID-19 vaccine. However, there have been reports of allergic reactions to the vaccine, which may be due to the PEG component of ALC-0159. These reactions are rare and are usually mild to moderate in severity.
See also
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
