ACOT13

ACOT13 is a gene that encodes the enzyme Acyl-CoA thioesterase 13 in humans. This enzyme is part of the Acyl-CoA thioesterase family, which is involved in the metabolism of fatty acids.

Function

The ACOT13 gene provides instructions for making an enzyme that is found in the mitochondria, the energy-producing centers of cells. This enzyme is involved in the breakdown of certain types of fatty acids, specifically very long-chain fatty acids. By breaking down these fatty acids, the enzyme helps to control the amount of fatty acids in cells and tissues.

Clinical significance

Mutations in the ACOT13 gene have been associated with a variety of health conditions. For example, some studies have suggested a link between variations in this gene and an increased risk of obesity and type 2 diabetes. However, more research is needed to confirm these findings and understand the exact role of ACOT13 in these conditions.

See also

• Acyl-CoA thioesterase
• Fatty acid metabolism
• Mitochondria

References

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.