8-OH-DPAT

8-OH-DPAT

Chemical structure of 8-OH-DPAT

8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) is a research chemical that acts as a selective agonist of the 5-HT1A receptor, a subtype of the serotonin receptor. It is commonly used in scientific research to study the role of the 5-HT1A receptor in various physiological and behavioral processes.

Pharmacology

8-OH-DPAT is known for its high affinity and selectivity for the 5-HT1A receptor, which is a G protein-coupled receptor (GPCR) involved in the modulation of serotonin levels in the brain. Activation of this receptor by 8-OH-DPAT can lead to various effects, including changes in mood, anxiety, and thermoregulation.

Mechanism of Action

8-OH-DPAT binds to the 5-HT1A receptor, which is primarily located in the central nervous system (CNS). Upon binding, it activates the receptor, leading to the inhibition of adenylate cyclase activity and a decrease in the production of cyclic AMP (cAMP). This results in the modulation of neurotransmitter release and neuronal excitability.

Uses in Research

8-OH-DPAT is widely used in neuroscience research to investigate the role of the 5-HT1A receptor in various conditions, such as depression, anxiety disorders, and schizophrenia. It is also used to study the effects of serotonin on thermoregulation and sexual behavior in animal models.

Behavioral Studies

In behavioral studies, 8-OH-DPAT is often used to assess its anxiolytic and antidepressant-like effects. It has been shown to reduce anxiety-like behavior in the elevated plus maze and open field test in rodents.

Physiological Studies

8-OH-DPAT is also used to study its effects on body temperature regulation. It has been observed to induce hypothermia in rodents, which is thought to be mediated by its action on the 5-HT1A receptor.

Related Compounds

8-OH-DPAT is part of a class of compounds known as serotonin receptor agonists. Other related compounds include buspirone, tandospirone, and flesinoxan, which also target the 5-HT1A receptor but may have different selectivity and efficacy profiles.

Related Pages

• Serotonin receptor
• 5-HT1A receptor
• Neurotransmitter
• G protein-coupled receptor