4-Ipomeanol
4-Ipomeanol
4-Ipomeanol is a toxic compound found in certain plants of the genus Ipomoea. It is known for its potent respiratory toxicity and has been extensively studied for its effects on the lungs.
Chemical Properties
4-Ipomeanol is a furan-containing compound with the chemical formula C10H10O3. It is a colorless liquid at room temperature and is soluble in organic solvents.
Toxicity
Exposure to 4-Ipomeanol can result in severe lung damage, including pulmonary edema and fibrosis. The mechanism of toxicity involves the metabolism of 4-Ipomeanol to a reactive metabolite that causes oxidative stress and inflammation in the lungs.
Biological Effects
Studies have shown that 4-Ipomeanol can induce oxidative stress and DNA damage in lung cells. It can also disrupt cellular signaling pathways involved in lung function and repair.
Research
Research on 4-Ipomeanol is ongoing to better understand its mechanisms of toxicity and to develop potential treatments for lung injury caused by exposure to this compound.
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Contributors: Prab R. Tumpati, MD