2-Me-PVP

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2-Me-PVP

Chemical structure of 2-Me-PVP

2-Me-PVP (2-Methyl-_-pyrrolidinopropiophenone) is a synthetic stimulant of the cathinone class. It is chemically related to _-PVP (alpha-Pyrrolidinopentiophenone) and is known for its psychoactive effects. This compound has been used in scientific research and has also appeared in the recreational drug market.

Chemical Properties

2-Me-PVP is a derivative of pyrrolidinophenone, characterized by the presence of a pyrrolidine ring attached to the ketone moiety. The "2-Me" prefix indicates the presence of a methyl group at the second position of the pyrrolidine ring, which distinguishes it from other similar compounds.

Pharmacology

2-Me-PVP acts as a central nervous system stimulant. It is believed to exert its effects by inhibiting the reuptake of dopamine and norepinephrine, leading to increased concentrations of these neurotransmitters in the synaptic cleft. This mechanism is similar to that of other stimulants such as amphetamine and methylphenidate.

Effects

The effects of 2-Me-PVP are reported to include increased alertness, euphoria, and enhanced cognitive function. However, it can also cause adverse effects such as anxiety, paranoia, and cardiovascular issues. The intensity and duration of these effects can vary depending on the dose and route of administration.

Legal Status

The legal status of 2-Me-PVP varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In others, it may be unregulated or fall under analogue laws that control substances similar to those already banned.

Synthesis

The synthesis of 2-Me-PVP involves the reaction of a propiophenone derivative with a pyrrolidine compound. The process typically requires careful control of reaction conditions to ensure the correct substitution pattern on the pyrrolidine ring.

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Contributors: Prab R. Tumpati, MD