2-Deoxy-D-glucose
2-Deoxy-D-glucose
2-Deoxy-D-glucose (pronunciation: two-de-oxy-dee-gloo-cose) is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, hence the name 2-deoxy. It is a glucose analog that is readily taken up by glucose-transporting proteins, but it cannot be further metabolized into glucose-6-phosphate by hexokinase.
Etymology
The term 2-Deoxy-D-glucose is derived from the Greek word 'deoxy' meaning 'lacking oxygen' and 'glucose' which is derived from the Greek word 'glykys' meaning 'sweet'. The 'D' in the name refers to the configuration of the glucose molecule.
Usage
2-Deoxy-D-glucose is used in medical research to inhibit glycolysis. This is done to understand the effects of glucose deprivation on various types of cells and organisms. It is also used in 2-DG PET scans to measure the rate at which the heart uses glucose.
Related Terms
- Glucose: A simple sugar that is an important energy source in living organisms and is a component of many carbohydrates.
- Glycolysis: The metabolic pathway that converts glucose into pyruvate.
- Hexokinase: An enzyme that phosphorylates hexoses, forming hexose phosphate.
- PET scan: A type of imaging test that helps reveal how your tissues and organs are functioning.
External links
- Medical encyclopedia article on 2-Deoxy-D-glucose
- Wikipedia's article - 2-Deoxy-D-glucose
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