2β-Propanoyl-3β-(2-naphthyl)-tropane

2β-Propanoyl-3β-(2-naphthyl)-tropane‏‎ or WF-23 is a synthetic cocaine analogue. It is a potent stimulant and a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).

Chemistry

2β-Propanoyl-3β-(2-naphthyl)-tropane‏‎ is a tropane derivative, which is a class of compounds that includes natural alkaloids such as cocaine and synthetic analogues like RTI-111. The compound is structurally similar to cocaine, with the key difference being the replacement of the benzoyl group in cocaine with a propanoyl group, and the replacement of the tropane ring's N-methyl group with a 2-naphthyl group.

Pharmacology

As a SNDRI, 2β-Propanoyl-3β-(2-naphthyl)-tropane‏‎ inhibits the reuptake of the neurotransmitters serotonin, norepinephrine, and dopamine, increasing their levels in the brain and resulting in stimulant effects. The compound has been found to be more potent than cocaine in binding to the dopamine transporter and producing locomotor stimulation in animals.

Research and Potential Uses

Research into 2β-Propanoyl-3β-(2-naphthyl)-tropane‏‎ and similar compounds is primarily focused on their potential use in the treatment of cocaine addiction. The compound's high potency and long duration of action make it a potential candidate for use in medication-assisted treatment (MAT) for cocaine dependence. However, further research is needed to determine the safety and efficacy of this approach.

See Also

• Cocaine analogue
• Tropane
• Serotonin-norepinephrine-dopamine reuptake inhibitor

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