Opioid overdose

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Opioid overdose
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Decreased consciousness, pinpoint pupils, respiratory depression
Complications	Rhabdomyolysis, brain damage, death
Onset	Rapid
Duration	Variable
Types	N/A
Causes	Opioid use
Risks	Substance use disorder, high-dose opioid therapy, concurrent use of sedatives
Diagnosis	Based on clinical presentation and history of opioid use
Differential diagnosis	Benzodiazepine overdose, alcohol intoxication, hypoglycemia
Prevention	Opioid substitution therapy, naloxone distribution
Treatment	Naloxone, supportive care
Medication	N/A
Prognosis	Good with prompt treatment
Frequency	Common
Deaths	Hundreds of thousands globally per year

An article about opioid overdose, its causes, symptoms, and treatment.

Opioid overdose is a medical condition that occurs when a person consumes an excessive amount of opioids, leading to potentially life-threatening symptoms. Opioids are a class of drugs that include both prescription medications, such as morphine, oxycodone, and fentanyl, as well as illegal drugs like heroin.

Causes

Opioid overdose can occur due to several reasons, including:

• Taking a higher dose than prescribed.
• Using opioids in combination with other depressants, such as alcohol or benzodiazepines.
• Using opioids after a period of abstinence, which reduces tolerance.
• Accidental ingestion, especially in children.

Symptoms

The symptoms of opioid overdose are primarily due to the drug's effects on the central nervous system and include:

• Severe respiratory depression, which can lead to hypoxia and death.
• Miosis, or pinpoint pupils, as shown in the image

  

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• Unconsciousness or inability to wake up.
• Limp body and pale, clammy skin.
• Slow or absent pulse.

Diagnosis

Diagnosis of opioid overdose is primarily clinical, based on the presentation of symptoms and history of opioid use. Toxicology screens can confirm the presence of opioids in the system.

Treatment

The primary treatment for opioid overdose is the administration of naloxone, an opioid antagonist that can rapidly reverse the effects of opioids. Naloxone can be administered intravenously, intramuscularly, or intranasally. Supportive care, including ensuring adequate ventilation and oxygenation, is also critical. In severe cases, advanced life support measures may be necessary.

Prevention

Preventing opioid overdose involves several strategies, including:

• Educating patients and healthcare providers about the risks of opioid use.
• Implementing prescription drug monitoring programs.
• Increasing access to naloxone for individuals at risk of overdose.
• Encouraging the use of medication-assisted treatment (MAT) for opioid use disorder.

Public Health Impact

Opioid overdose is a significant public health issue, contributing to thousands of deaths annually worldwide. The opioid epidemic has highlighted the need for comprehensive strategies to address opioid misuse and overdose.

Also see

• Opioid epidemic
• Naloxone
• Opioid use disorder
• Respiratory depression