Purpura fulminans

Purpura fulminans
Synonyms
Pronounce	N/A
Specialty	N/A
Symptoms	Purpura, necrosis, disseminated intravascular coagulation
Complications	Sepsis, organ failure, amputation
Onset	Sudden
Duration
Types	N/A
Causes	Bacterial infection, genetic disorder, anticoagulant protein deficiency
Risks	Infection, genetic predisposition
Diagnosis	Clinical presentation, blood tests, skin biopsy
Differential diagnosis	Meningococcemia, sepsis, thrombocytopenic purpura
Prevention	N/A
Treatment	Antibiotics, anticoagulation therapy, supportive care
Medication	Heparin, fresh frozen plasma, protein C concentrate
Prognosis	Variable, depends on severity and treatment
Frequency	Rare
Deaths	N/A

Purpura Fulminans is a severe and rapidly progressive condition characterized by blood clots and hemorrhage into the skin and other organs. It is a medical emergency that requires immediate treatment.

Causes

Purpura Fulminans is often caused by severe infections, particularly meningococcal sepsis. It can also occur as a complication of disseminated intravascular coagulation (DIC), a condition in which blood clots form throughout the body's small blood vessels.

Symptoms

The main symptom of Purpura Fulminans is the sudden appearance of numerous areas of skin necrosis and hemorrhage (bleeding) into the skin. These areas are initially purplish-red and then become black as the skin and underlying tissues die. Other symptoms can include fever, shock, and organ failure.

Diagnosis

The diagnosis of Purpura Fulminans is based on the clinical presentation and laboratory tests. These tests may include blood cultures to identify the underlying infection, and tests to evaluate the coagulation system, such as a prothrombin time (PT) and partial thromboplastin time (PTT).

Treatment

Treatment of Purpura Fulminans involves addressing the underlying cause, such as treating the infection with antibiotics. Supportive care, including fluid resuscitation and vasopressors, may be needed to maintain blood pressure. In severe cases, amputation of affected limbs may be necessary.

Prognosis

The prognosis of Purpura Fulminans is often poor, with a high mortality rate. Early diagnosis and treatment can improve the outcome.

See also

• Disseminated intravascular coagulation
• Meningococcal sepsis
• Skin necrosis
• Hemorrhage

This article is a medical stub. You can help WikiMD by expanding it!
Most recent articles Ongoing trials	Wikipedia