Methasterone

Methasterone

Methasterone chemical structure

Methasterone, also known as methyldrostanolone, is an orally active anabolic-androgenic steroid (AAS) that was never marketed for medical use. It is a derivative of dihydrotestosterone (DHT) and is known for its potent anabolic effects with relatively low androgenic properties. Methasterone gained popularity as a designer steroid and was sold under various brand names as a dietary supplement before being classified as a controlled substance.

Chemical Structure and Properties

Methasterone is a 17α-alkylated derivative of drostanolone, which is itself a derivative of DHT. The chemical structure of methasterone is characterized by the addition of a methyl group at the 17α position, which enhances its oral bioavailability. This modification also increases the compound's resistance to hepatic metabolism, allowing it to exert its effects when taken orally.

The molecular formula of methasterone is C21H34O2, and it has a molecular weight of 318.493 g/mol. The compound is known for its high anabolic to androgenic ratio, making it effective for muscle growth with fewer androgenic side effects compared to other steroids.

Pharmacology

Methasterone functions by binding to the androgen receptor, which leads to an increase in protein synthesis and muscle growth. Its anabolic effects are primarily due to its ability to enhance nitrogen retention and promote the synthesis of muscle proteins. The compound also has a moderate effect on increasing red blood cell production, which can improve endurance and recovery.

Despite its anabolic benefits, methasterone is associated with significant hepatotoxicity due to its 17α-alkylated structure. This can lead to liver damage with prolonged use or high dosages. Other potential side effects include hypertension, dyslipidemia, and testosterone suppression.

Legal Status

Methasterone was initially sold as a dietary supplement under various brand names, such as "Superdrol," without being classified as a controlled substance. However, due to its potent anabolic effects and associated health risks, it was eventually added to the list of controlled substances in many countries. In the United States, methasterone is classified as a Schedule III controlled substance under the Anabolic Steroid Control Act.

Usage and Doping

Methasterone has been used by athletes and bodybuilders to enhance performance and muscle mass. Its use in sports is considered doping, and it is banned by the World Anti-Doping Agency (WADA) and other sports organizations. The detection of methasterone in athletes is typically conducted through urine analysis using mass spectrometry.

Health Risks and Side Effects

The use of methasterone is associated with several health risks, primarily due to its hepatotoxic nature. Users may experience liver damage, which can manifest as elevated liver enzymes, jaundice, and in severe cases, liver failure. Other side effects include acne, hair loss, gynecomastia, and testicular atrophy.

Due to its impact on cholesterol levels, methasterone can increase the risk of cardiovascular diseases by lowering high-density lipoprotein (HDL) and increasing low-density lipoprotein (LDL) levels. Users are advised to monitor their health closely and avoid prolonged use.

Related Pages

• Anabolic steroid
• Dihydrotestosterone
• Drostanolone
• Hepatotoxicity
• World Anti-Doping Agency