Tachykinin receptor 1

Tachykinin receptor 1 (TACR1) is a protein that in humans is encoded by the TACR1 gene. It is a member of the tachykinin receptor family, a group of G-protein coupled receptors that are targeted by the tachykinin family of peptides.

Function

TACR1 is one of the three known receptors for the tachykinin family of peptides. It is activated by the endogenous substances substance P, neurokinin A, and neurokinin B. The activation of TACR1 leads to a variety of physiological responses including salivation, smooth muscle contraction, and pain transmission.

Clinical significance

Alterations in the function of TACR1 have been implicated in various diseases, such as migraine, asthma, vomiting, and pain. Antagonists of TACR1 are being investigated for their potential as therapeutic agents in these conditions.

Pharmacology

Several drugs have been developed that act as antagonists at the TACR1 receptor, including aprepitant, fosaprepitant, and vofopitant. These drugs are used in the treatment of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

See also

• Tachykinin receptor 2
• Tachykinin receptor 3

References

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