Pegol

Pegol is a suffix used in pharmacology to denote PEGylation, a process that involves the covalent attachment of polyethylene glycol (PEG) to a drug or therapeutic protein. This process can increase the drug's stability and solubility, reduce immunogenicity, and extend the circulating life of the drug in the body.

History

The term "pegol" was first introduced by the United States Adopted Names (USAN) Council to denote drugs that have undergone PEGylation. The USAN Council is responsible for the selection of nonproprietary (generic) names for drugs, a critical component of the drug approval process.

Mechanism of Action

PEGylation works by attaching PEG to a drug or therapeutic protein, which can alter the drug's properties. The PEG can shield the drug from the immune system, reducing immunogenicity and potentially reducing side effects. It can also increase the drug's solubility, which can improve its absorption and distribution in the body. Finally, PEGylation can extend the circulating life of the drug, allowing for less frequent dosing.

Examples of Pegol Drugs

Several drugs that have undergone PEGylation use the "pegol" suffix. These include:

• Certolizumab pegol, used to treat rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
• Etelcalcetide pegol, used to treat secondary hyperparathyroidism in patients with chronic kidney disease.
• Mogamulizumab pegol, used to treat certain types of lymphoma.
• Otelixizumab pegol, used to treat type 1 diabetes.

See Also

• PEGylation
• United States Adopted Names
• Certolizumab pegol
• Etelcalcetide pegol
• Mogamulizumab pegol
• Otelixizumab pegol

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