1H-LSD

Chemical compound related to LSD

1H-LSD
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

1H-LSD is a chemical compound that is structurally related to the well-known psychedelic drug LSD (lysergic acid diethylamide). It is a derivative of LSD, where the indole nitrogen is hydrogenated, resulting in a different chemical structure and potentially different pharmacological properties.

Chemical Structure and Properties

Chemical structure of 1H-LSD

1H-LSD is characterized by the hydrogenation of the indole nitrogen in the LSD molecule. This modification results in a compound with the molecular formula C20H27N3O. The systematic IUPAC name for 1H-LSD is (6aR,9R)-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide.

The hydrogenation of the indole nitrogen in 1H-LSD distinguishes it from LSD, which has a double bond at this position. This structural change may influence the compound's interaction with serotonin receptors in the brain, potentially altering its psychoactive effects.

Pharmacology

The pharmacological effects of 1H-LSD are not as well-studied as those of LSD. However, it is believed that 1H-LSD, like LSD, acts primarily as an agonist at the 5-HT2A receptor, a subtype of serotonin receptor. This receptor is thought to play a key role in the psychedelic effects of LSD and related compounds.

Due to the structural similarity to LSD, 1H-LSD may exhibit similar effects, such as altered perception, mood changes, and cognitive shifts. However, the specific effects and potency of 1H-LSD compared to LSD are not well-documented in scientific literature.

Legal Status

The legal status of 1H-LSD varies by country. In many jurisdictions, it may be considered a controlled substance due to its structural similarity to LSD. However, specific regulations may differ, and it is important to consult local laws regarding the possession and use of 1H-LSD.

Research and Applications

Research on 1H-LSD is limited, and it is primarily of interest in the field of psychedelic research and neuropharmacology. Scientists may study 1H-LSD to better understand the structure-activity relationships of LSD and its analogs, as well as to explore potential therapeutic applications of psychedelic compounds.

Related Compounds

1H-LSD is part of a broader class of compounds known as lysergamides, which includes LSD and other derivatives. These compounds are characterized by their structural similarity to lysergic acid and their potential psychoactive effects.

Related Pages

• LSD
• Psychedelic drug
• Serotonin receptor
• Lysergamide