Estrone/progesterone

Estrone/progesterone is a combination of two hormones, estrone and progesterone, which are used in hormone replacement therapy (HRT). This therapy is often prescribed for women who are experiencing symptoms of menopause.

Estrone

Estrone is a type of estrogen, the primary female sex hormone. It is one of three main estrogens produced by the body, along with estradiol and estriol. Estrone is primarily produced in the ovaries, adipose tissue (fat), and the adrenal glands. It plays a crucial role in the regulation of the menstrual cycle and the development of female secondary sexual characteristics.

Progesterone

Progesterone is a hormone produced by the ovaries that plays a key role in the menstrual cycle and in pregnancy. It prepares the body for pregnancy by causing the lining of the uterus to thicken. If pregnancy does not occur, progesterone levels drop, triggering the start of a menstrual period.

Hormone Replacement Therapy

Hormone replacement therapy (HRT) is a treatment used to relieve symptoms of menopause. It replaces hormones that are at a lower level as you approach the menopause. The main benefits of HRT are that it can help relieve most of the menopausal symptoms, such as hot flushes, night sweats, mood swings, vaginal dryness and reduced sex drive.

Side Effects

Like all medications, estrone/progesterone can have side effects. These may include nausea, vomiting, bloating, breast tenderness, headache, or weight changes. If these effects persist or worsen, tell your doctor or pharmacist promptly.

Precautions

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, thyroid disease, certain types of cancers (e.g., breast cancer, cancer of the uterus/ovaries), blood clots, stroke, heart disease (e.g., heart attacks), high blood pressure, diabetes, high cholesterol levels, migraine, lupus, seizures, or depression.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

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