Abetimus
A synthetic drug used in the treatment of systemic lupus erythematosus
Abetimus is a synthetic oligonucleotide drug designed for the treatment of systemic lupus erythematosus (SLE), an autoimmune disease characterized by the production of autoantibodies against the body's own tissues. Abetimus is specifically engineered to reduce the levels of anti-double-stranded DNA antibodies, which are implicated in the pathogenesis of SLE.
Mechanism of Action
Abetimus functions by acting as a decoy for anti-DNA antibodies. It is composed of four double-stranded DNA sequences attached to a polyethylene glycol (PEG) backbone. These sequences mimic the structure of native DNA, allowing abetimus to bind to circulating anti-DNA antibodies. This binding reduces the availability of these antibodies to interact with the body's own DNA, thereby decreasing the inflammatory response and tissue damage associated with SLE.
Clinical Use
Abetimus is used as a therapeutic agent in patients with systemic lupus erythematosus who have high levels of anti-DNA antibodies. By lowering these antibody levels, abetimus can help to manage the symptoms of SLE and prevent flares. However, its use is limited to specific cases and it is not a first-line treatment.
Development and Approval
Abetimus was developed as a novel approach to treating autoimmune diseases by targeting specific autoantibodies. Despite its innovative mechanism, the clinical development of abetimus faced challenges, and it has not been widely adopted in clinical practice. The drug's approval status and availability may vary by region.
Side Effects
The administration of abetimus can lead to side effects, which may include injection site reactions, allergic reactions, and potential immunosuppression. Patients receiving abetimus should be monitored for these adverse effects, and the treatment should be adjusted accordingly.
Related pages
Gallery
-
Structure of Abetimus
Ad. Transform your life with W8MD's Budget GLP-1 injections from $49.99
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Weight loss injections in NYC (generic and brand names):
- Zepbound / Mounjaro, Wegovy / Ozempic, Saxenda
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $49.99 for the starting dose of Semaglutide and $65.00 for Tirzepatide.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointmentsNYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
