5-Carboxamidotryptamine

A chemical compound related to serotonin

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative that acts as a potent serotonin receptor agonist. It is primarily used in scientific research to study the function of serotonin receptors in the central nervous system.

Chemical structure and properties

5-Carboxamidotryptamine is a synthetic compound that belongs to the class of tryptamines, which are structurally related to the neurotransmitter serotonin. The chemical structure of 5-CT includes an indole ring, which is a common feature of tryptamines, and a carboxamido group at the 5-position of the indole ring.

Pharmacology

5-CT is known for its high affinity and selectivity for several subtypes of serotonin receptors, including the 5-HT1A receptor, 5-HT1B receptor, and 5-HT7 receptor. It is often used in research to explore the physiological and behavioral effects mediated by these receptors.

Receptor binding

5-CT binds to serotonin receptors with high affinity, mimicking the action of serotonin. This makes it a valuable tool in pharmacological studies aimed at understanding the role of serotonin in various biological processes.

Effects

In experimental settings, 5-CT has been shown to produce a range of effects, including modulation of mood, anxiety, and thermoregulation. Its action on the 5-HT1A receptor, in particular, is associated with anxiolytic and antidepressant-like effects in animal models.

Applications in research

5-Carboxamidotryptamine is widely used in neuroscience research to investigate the role of serotonin in the brain. It helps in elucidating the mechanisms underlying psychiatric disorders such as depression, anxiety disorders, and schizophrenia.

Safety and handling

As with many research chemicals, 5-CT should be handled with care in a laboratory setting. Appropriate safety measures, including the use of personal protective equipment, should be followed to prevent exposure.

Related pages

• Serotonin
• Tryptamine
• Serotonin receptor
• Neurotransmitter

Gallery

• 
  Chemical structure of 5-Carboxamidotryptamine