Thyrotoxic myopathy

Thyrotoxic myopathy is a neuromuscular disorder that may accompany hyperthyroidism (Graves' disease, caused by overproduction of the thyroid hormone thyroxine).

Symptoms

Symptoms may include muscle weakness, myalgias (muscle tenderness), wasting of the pelvic girdle and shoulder muscles, fatigue, and/or heat intolerance.

Associated conditions

Thyroid myopathy may be associated with rhabdomyolysis (acute muscle breakdown), damage to the muscles that control eye movement, and temporary, but severe, attacks of muscle weakness that are associated with low blood potassium levels (known as periodic paralysis).

Prognosis

Prognosis is good with proper diagnosis and treatment.

Treatment

Treatment involves treated the underlying thyrotoxicosis and may include thyroid drugs, radioactive iodine, and sometimes partial or complete surgical removal of the thyroid.  

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