Aramchol

Arachidyl amido cholanoic acid

Aramchol is a synthetic lipid molecule that has been investigated for its potential therapeutic effects in treating non-alcoholic steatohepatitis (NASH) and other liver-related diseases. It is a conjugate of arachidic acid and cholic acid, designed to modulate lipid metabolism and reduce liver fat content.

Mechanism of Action

Aramchol works by inhibiting the enzyme stearoyl-CoA desaturase 1 (SCD1), which plays a crucial role in the synthesis of monounsaturated fats from saturated fats. By inhibiting SCD1, Aramchol reduces the accumulation of fat in the liver, thereby addressing one of the key pathological features of NASH.

Clinical Trials

Aramchol has undergone several phases of clinical trials to evaluate its safety and efficacy. In early-phase trials, Aramchol demonstrated a significant reduction in liver fat content and improvement in liver function markers. Ongoing studies aim to further establish its therapeutic potential and long-term safety profile.

Potential Benefits

The primary benefits of Aramchol include:

• Reduction in liver fat content
• Improvement in liver function tests
• Potential to halt or reverse the progression of NASH

Side Effects

As with any therapeutic agent, Aramchol may have side effects. Commonly reported side effects include gastrointestinal disturbances, such as nausea and diarrhea. Long-term safety data are still being collected through ongoing clinical trials.

Related Pages

• Non-alcoholic steatohepatitis
• Liver disease
• Stearoyl-CoA desaturase 1
• Lipid metabolism
• Clinical trials

See Also

• Fatty liver disease
• Hepatology
• Metabolic syndrome

External Links

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