GATA5

GATA5 is a gene that in humans is encoded by the GATA5 protein. It is a member of the GATA family of zinc finger proteins. These proteins are named for the GATA motif, a zinc finger DNA-binding domain that recognizes the sequence G-A-T-A. GATA5 is known to play a crucial role in the development and differentiation of multiple organ systems.

Function

GATA5 is a transcription factor that binds to the zinc finger domain of DNA and controls the transcription of downstream genes. It is involved in the development of the heart, gastrointestinal tract, and nervous system. GATA5 is also implicated in the regulation of cell differentiation and cell proliferation.

Clinical significance

Mutations in the GATA5 gene have been associated with a variety of congenital heart defects, including atrial septal defect, ventricular septal defect, and tetralogy of Fallot. These conditions can lead to symptoms such as shortness of breath, fatigue, and heart palpitations.

File:GATA5 gene location.png

Location of the GATA5 gene on chromosome 20

Research

Research into the GATA5 gene and its associated proteins is ongoing. Studies have suggested that GATA5 may also play a role in the development of certain types of cancer, including gastric cancer and colorectal cancer. Further research is needed to fully understand the role of GATA5 in these conditions.

See also

• GATA transcription factor
• Zinc finger protein
• Congenital heart defect

References

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