Cefamandole

Cefamandole is a second-generation cephalosporin antibiotic. It is primarily used in the treatment of bacterial infections caused by susceptible organisms. Cefamandole is not commonly used today due to the availability of newer, more effective antibiotics.

History

Cefamandole was first synthesized in the 1970s as part of a wave of new cephalosporin antibiotics. It was developed by the pharmaceutical company Eli Lilly, and was marketed under the brand name Mandol.

Medical uses

Cefamandole is used to treat a variety of bacterial infections, including those caused by Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli. It is also effective against some strains of Pseudomonas aeruginosa and Klebsiella species.

Pharmacology

Cefamandole works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. It is a beta-lactam antibiotic, and its mechanism of action is similar to that of other cephalosporins.

Side effects

Common side effects of cefamandole include gastrointestinal upset, rash, and hypersensitivity reactions. Like other cephalosporins, it can also cause Clostridium difficile-associated diarrhea.

Drug interactions

Cefamandole can interact with other medications, including warfarin and other blood thinners. It can also cause a disulfiram-like reaction when taken with alcohol.

See also

• Cephalosporin
• Antibiotics
• Bacterial infection