Piminodine

Piminodine is an opioid analgesic that is an analog of pethidine (meperidine). It was developed by Hoffmann-La Roche in the 1950s. Piminodine has similar effects to other opioids, and produces analgesia, sedation and euphoria. Side effects can include itching, nausea and respiratory depression.

Pharmacology

Piminodine is a mu-opioid receptor agonist. It is around as potent as meperidine as an analgesic, but has a longer duration of action. Piminodine is metabolized in the liver, and its metabolites are excreted by the kidneys.

Chemistry

Piminodine is a 4-phenylpiperidine derivative that is structurally related to the opioid analgesic drug pethidine. The only difference is that the N-methyl group of pethidine is replaced by an N-phenethyl group, which is the structural feature that turns it into a potent opioid agonist.

History

Piminodine was first synthesized by Hoffmann-La Roche in the 1950s, along with a variety of other analogs of pethidine, in an attempt to find synthetic opioids with improved pharmacological properties compared to the natural opium alkaloids which were the mainstay of analgesic therapy at the time.

Legal Status

Piminodine is a Schedule II drug under the Convention on Psychotropic Substances. In the United States, it is a Schedule II controlled substance. The DEA number is 9737.

See Also

• Opioid
• Analgesic
• Pethidine
• Hoffmann-La Roche

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