Trapidil

Trapidil is a vasodilator and platelet aggregation inhibitor that is used in the treatment of vascular disease. It is a derivative of pyrimido-pyrimidine, and it works by inhibiting the release of growth factors from platelets, which in turn inhibits smooth muscle growth. This makes it useful in the treatment of conditions such as atherosclerosis and restenosis.

Mechanism of Action

Trapidil acts as an antagonist of the platelet-derived growth factor (PDGF) receptor. PDGF is a potent stimulator of growth for vascular smooth muscle cells, and its inhibition by Trapidil helps to prevent the proliferation of these cells, which is a key factor in the development of atherosclerosis and restenosis.

Clinical Uses

Trapidil is used in the treatment of various vascular diseases, including atherosclerosis and restenosis. It is also used in the prevention of coronary artery disease, and in the treatment of pulmonary hypertension.

Side Effects

Like all medications, Trapidil can cause side effects. These can include nausea, vomiting, diarrhea, and abdominal pain. In rare cases, it can cause serious side effects such as liver damage or bleeding.

Contraindications

Trapidil should not be used in patients with known hypersensitivity to the drug. It should also be used with caution in patients with liver disease or bleeding disorders.

See Also

• Vasodilator
• Platelet aggregation inhibitor
• Atherosclerosis
• Restenosis

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