Pseudoporphyria

Pseudoporphyria is a rare skin condition that mimics the symptoms and signs of porphyria cutanea tarda without the accompanying biochemical defect of the heme synthesis pathway. It is also known as false porphyria.

Causes

Pseudoporphyria is often associated with exposure to certain medications or substances. These include nonsteroidal anti-inflammatory drugs (NSAIDs), tetracyclines, and furosemide. It can also be caused by chronic kidney disease and dialysis.

Symptoms

The symptoms of pseudoporphyria are similar to those of porphyria cutanea tarda. They include skin fragility, blistering, and increased pigmentation, especially on areas of the skin exposed to the sun. Other symptoms may include itching, redness, and swelling.

Diagnosis

Diagnosis of pseudoporphyria is based on the clinical presentation and history of the patient. Laboratory tests are typically normal, unlike in true porphyria where there are specific abnormalities in the heme synthesis pathway. A skin biopsy may be performed to confirm the diagnosis.

Treatment

Treatment of pseudoporphyria involves identifying and removing the underlying cause, such as discontinuing the use of certain medications. Protective clothing and sun avoidance are also recommended. In severe cases, medication may be prescribed to reduce the symptoms.

See also

• Porphyria
• Porphyria cutanea tarda
• Nonsteroidal anti-inflammatory drug
• Tetracycline
• Furosemide

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