Nonsteroidal antiandrogen

Nonsteroidal antiandrogens are a class of drugs that prevent androgens (male hormones) from binding to androgen receptors in the body. They are used in the treatment of prostate cancer and other conditions.

Mechanism of action

Nonsteroidal antiandrogens work by blocking the action of androgens. They do this by binding to the androgen receptor, preventing androgens from doing so. This inhibits the growth of prostate cancer cells, which rely on androgens for growth.

Uses

Nonsteroidal antiandrogens are primarily used in the treatment of prostate cancer. They may be used alone or in combination with other treatments, such as surgery, radiation therapy, or chemotherapy. They may also be used to treat other conditions that are influenced by androgens, such as hirsutism (excessive hair growth) in women.

Side effects

Like all medications, nonsteroidal antiandrogens can cause side effects. These may include hot flashes, fatigue, nausea, and diarrhea. They can also cause sexual side effects, such as decreased libido or erectile dysfunction.

Examples

Examples of nonsteroidal antiandrogens include flutamide, bicalutamide, and nilutamide. These drugs are all taken orally.

See also

• Androgen deprivation therapy
• Hormone therapy for prostate cancer
• Androgen receptor

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