CD86

CD86 (also known as B7-2) is a protein that in humans is encoded by the CD86 gene. CD86 is a type of protein called a cell surface receptor that is expressed on antigen-presenting cells. It provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

Function

The CD86 protein is a member of the immunoglobulin superfamily. It is found on the surface of antigen-presenting cells including macrophages and dendritic cells. It provides a costimulatory signal which aids in the activation of T cells, a type of white blood cell that plays a central role in immunity. CD86 acts as a receptor for both CD28 and CTLA-4, proteins found on the surface of T cells.

Clinical significance

CD86 has been implicated in several diseases, including asthma, rheumatoid arthritis, and cancer. In cancer, it is thought to play a role in tumor evasion of the immune system. In autoimmune diseases like rheumatoid arthritis, it is thought to play a role in the inappropriate activation of the immune system.

Interactions

CD86 has been shown to interact with CD28 and CTLA4.

See also

• Cluster of differentiation
• CD80
• CTLA-4
• CD28

References

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External links

• CD86 at WikiMD

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