Hydrocodone/ibuprofen

Hydrocodone/Ibuprofen is a medication that combines an opioid pain reliever (hydrocodone) with a nonsteroidal anti-inflammatory drug (ibuprofen). It is used to relieve acute pain, such as pain following dental or surgical procedures.

Etymology

The term "hydrocodone" is derived from two words: "hydro" is a prefix meaning water, and "codone" is derived from codeine, a type of narcotic. "Ibuprofen" is derived from the words "isobutyl", "phenyl", and "propionic acid", which describe its chemical structure.

Pharmacology

Hydrocodone is a semi-synthetic opioid derived from codeine. It works by binding to the mu-opioid receptors in the brain, which are responsible for pain perception. Ibuprofen, on the other hand, works by inhibiting the production of prostaglandins, substances in the body that cause inflammation and pain.

Indications

Hydrocodone/Ibuprofen is indicated for the short-term management of acute pain severe enough to require an opioid analgesic and where alternative treatments are inadequate.

Contraindications

This medication is contraindicated in patients with significant respiratory depression, acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment, known or suspected gastrointestinal obstruction, and hypersensitivity to hydrocodone or ibuprofen.

Side Effects

Common side effects of Hydrocodone/Ibuprofen include nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness. Serious side effects may include slow/shallow breathing, severe drowsiness/difficulty waking up, confusion, hallucinations, severe stomach/abdominal pain, difficulty urinating, adrenal gland problems, and liver disease.

Interactions

Hydrocodone/Ibuprofen may interact with other medications, including other opioid pain or cough relievers, alcohol, marijuana, drugs for sleep or anxiety, muscle relaxants, and antihistamines.

See Also

• Opioid
• Nonsteroidal anti-inflammatory drug
• Pain management

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