List of fibrinogen disorders

Fibrinogen disorders are a set of hereditary or acquired abnormalities in the quantity and/or quality of circulating fibrinogens. The disorders may lead to pathological bleeding and/or blood clotting or the deposition of fibrinogen in the liver, kidneys, or other organs and tissues. These disorders include:

• Congenital afibrinogenemia, an inherited blood disorder in which blood does not clot normally due to the lack of fibrinogen; the disorder causes abnormal bleeding and thrombosis.<ref name="pmid27019462">,

 Clinical Features and Management of Congenital Fibrinogen Deficiencies, 
 Seminars in Thrombosis and Hemostasis, 
 2016,
 Vol. 42(Issue: 4),
 pp. 366–74,
 DOI: 10.1055/s-0036-1571339,
 PMID: 27019462,</ref>

• Congenital hypofibrinogenemia, an inherited disorder in which blood may not clot normally due to reduced levels of fibrinogen; the disorder may cause abnormal bleeding and thrombosis.<ref name="pmid27019462"/>
• Fibrinogen storage disease, a form of congenital hypofibrinogenemia in which specific hereditary mutations in fibrinogen cause it to accumulate in, and damage, liver cells. The disorder may lead to abnormal bleeding and thrombosis but also to cirrhosis.<ref name="pmid25990487">,

 Hypofibrinogenemia and liver disease: a new case of Aguadilla fibrinogen and review of the literature, 
 Haemophilia, 
 2015,
 Vol. 21(Issue: 6),
 pp. 820–7,
 DOI: 10.1111/hae.12719,
 PMID: 25990487,</ref>

• Congenital dysfibrinogenemia, an inherited disorder in which normal levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause abnormal bleeding and thrombosis.<ref name="pmid25816717">,

 Dysfibrinogenemia: from molecular anomalies to clinical manifestations and management, 
 Journal of Thrombosis and Haemostasis, 
 2015,
 Vol. 13(Issue: 6),
 pp. 909–19,
 DOI: 10.1111/jth.12916,
 PMID: 25816717,</ref>

• Hereditary fibrinogen Aα-Chain amyloidosis, a form of dysfibrinogenemia in which certain fibrinogen mutations cause blood fibrinogen to accumulate in the kidney and cause one type of familial renal amyloidosis; the disorder is not associated with abnormal bleeding or thrombosis.<ref name="pmid19073821">,

 Diagnosis, pathogenesis, treatment, and prognosis of hereditary fibrinogen A alpha-chain amyloidosis, 
 Journal of the American Society of Nephrology, 
 2009,
 Vol. 20(Issue: 2),
 pp. 444–51,
 DOI: 10.1681/ASN.2008060614,
 PMID: 19073821,
 PMC: 2637055,</ref> 

• Acquired dysfibrinogenemia, a disorder in which normal levels of fibrinogen are composed at least in part of a dysfunctional fibrinogen due to an acquired disorder (e.g. liver disease) that leads to the synthesis of an incorrectly glycosylated (i.e. wrong amount of sugar residues) added to an otherwise normal fibrinogen. The incorrectly glycosalated fibrinogen is dysfunctional and may cause pathological episodes of bleeding and/or blood clotting.<ref name="pmid27713652">,

 Acquired hypofibrinogenemia: current perspectives, 
 Journal of Blood Medicine, 
 2016,
 Vol. 7,
 pp. 217–225,
 DOI: 10.2147/JBM.S90693,
 PMID: 27713652,
 PMC: 5045218,</ref>

• Congenital hypodysfibrinogenemia, an inherited disorder in which low levels of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause pathological episodes of bleeding or blood clotting.<ref name="pmid28211264">,

 Genetics, diagnosis and clinical features of congenital hypodysfibrinogenemia: a systematic literature review and report of a novel mutation, 
 Journal of Thrombosis and Haemostasis, 
 2017,
 Vol. 15(Issue: 5),
 pp. 876–888,
 DOI: 10.1111/jth.13655,
 PMID: 28211264,</ref>

• Cryofibrinogenemia, an acquired disorder in which fibrinogen precipitates at cold temperatures and may lead to the intravascular precipitation of fibrinogen, fibrin, and other circulating proteins thereby causing the infarction of various tissues and bodily extremities.<ref name="pmid28550239">,

 Clinical conditions responsible for hyperviscosity and skin ulcers complications, 
 Clinical Hemorheology and Microcirculation, 
 2017,
 
 
 DOI: 10.3233/CH-160218,
 PMID: 28550239,
 
 
 Full text,</ref>

See also

• Fibrinogen#Fibrinogen disorders

References

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