Aminoquinoline

Aminoquinoline is a class of chemical compounds that consist of a quinoline ring system to which an amino group is attached. The parent compound is aminoquinoline itself, but more complex derivatives including antimalarial drugs such as chloroquine and amodiaquine are also classified as aminoquinolines.

Chemistry

Aminoquinolines are a type of heterocyclic compound. They are characterized by a quinoline ring system, which consists of a benzene ring fused to a pyridine ring. To this ring system, an amino group is attached at one of the carbon atoms. The position of the amino group can vary, leading to different isomers of aminoquinoline.

Pharmacology

Several aminoquinolines have important pharmacological properties. They are used as antimalarial drugs, with chloroquine and amodiaquine being two of the most well-known examples. These drugs work by inhibiting the growth of Plasmodium parasites, the organisms that cause malaria.

Chloroquine has also been investigated for its potential use in the treatment of COVID-19, although its effectiveness for this purpose is still under debate.

Synthesis

Aminoquinolines can be synthesized through several methods. One common method is the Skraup synthesis, which involves the reaction of aniline with glycerol in the presence of sulfuric acid and an oxidizing agent.

See also

• Quinoline
• Antimalarial medication
• Heterocyclic compound

References

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