Anaprazole

An overview of the proton pump inhibitor Anaprazole

Anaprazole is a proton pump inhibitor (PPI) used in the treatment of various conditions related to excessive stomach acid production. It is primarily indicated for the management of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome.

Mechanism of Action

Anaprazole functions by irreversibly inhibiting the H+/K+ ATPase enzyme system, commonly known as the gastric proton pump, located in the parietal cells of the stomach lining. This inhibition prevents the final step in the production of gastric acid, thereby reducing acid secretion.

Pharmacokinetics

Anaprazole is administered orally and is absorbed in the small intestine. It is a prodrug that requires activation in the acidic environment of the parietal cells. Once activated, it binds covalently to the proton pump, leading to a prolonged duration of action despite its relatively short plasma half-life.

Clinical Uses

Anaprazole is used in the treatment of:

• Gastroesophageal reflux disease (GERD)
• Peptic ulcer disease
• Zollinger-Ellison syndrome
• Erosive esophagitis

Side Effects

Common side effects of Anaprazole include:

• Headache
• Nausea
• Diarrhea
• Abdominal pain

Long-term use of PPIs like Anaprazole may be associated with an increased risk of bone fractures, kidney disease, and vitamin B12 deficiency.

Drug Interactions

Anaprazole may interact with other medications metabolized by the cytochrome P450 system, particularly CYP2C19. It can affect the absorption of drugs that require an acidic environment, such as ketoconazole and iron supplements.

Chemical Structure

Chemical structure of Anaprazole

Anaprazole belongs to the benzimidazole class of compounds and shares structural similarities with other PPIs.

Related Pages

• Proton pump inhibitor
• Gastroesophageal reflux disease
• Peptic ulcer disease
• Zollinger-Ellison syndrome