Vitamin B12 deficiency

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Vitamin B12 deficiency
Synonyms N/A
Pronounce N/A
Specialty N/A
Symptoms Fatigue, pallor, shortness of breath, neuropathy, glossitis, jaundice
Complications Megaloblastic anemia, neurological disorders, cognitive impairment
Onset Gradual
Duration Long-term
Types N/A
Causes Malabsorption, pernicious anemia, dietary deficiency, gastric bypass surgery
Risks Veganism, alcoholism, Crohn's disease, celiac disease
Diagnosis Complete blood count, serum vitamin B12 level, methylmalonic acid test, homocysteine test
Differential diagnosis Folate deficiency, iron deficiency anemia, hypothyroidism
Prevention Adequate dietary intake of vitamin B12, vitamin B12 supplementation
Treatment Vitamin B12 injections, oral vitamin B12 supplements
Medication Cyanocobalamin, hydroxocobalamin
Prognosis N/A
Frequency Common in older adults, rare in young people
Deaths Rare, if untreated can lead to severe complications


Vitamin B12 deficiency is a medical condition in which the body does not have enough vitamin B12 to function properly. This deficiency can lead to a variety of health problems, including anemia, neurological disorders, and cognitive impairments.

Causes[edit]

Vitamin B12 deficiency can be caused by several factors, including:

Symptoms[edit]

The symptoms of vitamin B12 deficiency can vary and may include:

  • Fatigue and weakness
  • Pale or jaundiced skin
  • Heart palpitations and shortness of breath
  • Neurological symptoms: Numbness or tingling in the hands and feet, difficulty walking, memory loss, and cognitive decline
  • Mouth ulcers and a swollen, inflamed tongue
  • Vision problems

Diagnosis[edit]

Vitamin B12 deficiency is typically diagnosed through a combination of:

  • Medical history and physical examination
  • Blood tests: Measuring levels of vitamin B12, methylmalonic acid, and homocysteine in the blood
  • Complete blood count (CBC): To check for anemia and other abnormalities

Treatment[edit]

Treatment for vitamin B12 deficiency depends on the underlying cause and may include:

  • Dietary changes: Increasing the intake of vitamin B12-rich foods, such as meat, fish, dairy products, and fortified cereals
  • Oral supplements: Vitamin B12 tablets or capsules
  • Intramuscular injections: For individuals with severe deficiency or malabsorption issues
  • Treating underlying conditions: Addressing any medical conditions that may be causing the deficiency

Prevention[edit]

Preventing vitamin B12 deficiency involves:

  • Maintaining a balanced diet: Including sufficient amounts of vitamin B12-rich foods
  • Regular monitoring: For individuals at risk, such as those with gastrointestinal disorders or those taking medications that affect vitamin B12 absorption
  • Supplementation: For individuals following a vegan or vegetarian diet, or those with conditions that affect absorption

See also[edit]

External links[edit]

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