Plasma cell leukemia

Plasma cell leukemia (PCL) is a rare and aggressive variant of multiple myeloma which involves high levels of plasma cells circulating in the peripheral blood. It is characterized by the presence of plasma cells in the blood and is classified as either primary or secondary PCL.

Classification

PCL is classified into two types: primary and secondary. Primary PCL is diagnosed when the disease is found at the initial presentation, while secondary PCL is diagnosed when the disease evolves from pre-existing multiple myeloma.

Symptoms

The symptoms of PCL are similar to those of multiple myeloma and may include bone pain, fatigue, and weakness. Other symptoms may include fever, infection, and bleeding.

Diagnosis

The diagnosis of PCL is based on the presence of high levels of plasma cells in the blood. This can be determined through a blood test or a bone marrow biopsy.

Treatment

The treatment for PCL typically involves chemotherapy, stem cell transplantation, and supportive care. The choice of treatment depends on the patient's overall health and the specific characteristics of the disease.

Prognosis

The prognosis for PCL is generally poor, with a median survival time of less than a year. However, some patients may respond well to treatment and achieve a longer survival time.

See also

• Multiple myeloma
• Leukemia
• Plasma cell

References

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