Clocapramine

Clocapramine is a type of antipsychotic medication that is classified as a dibenzazepine derivative. It was developed in the 1960s by the Japanese pharmaceutical company Yamanouchi Pharmaceutical Co. and is primarily used in Japan and Hong Kong. Clocapramine is used to treat a variety of mental health conditions, including schizophrenia, anxiety disorders, and mood disorders.

Etymology

The name "clocapramine" is derived from the chemical structure of the drug, which is a dibenzazepine derivative. The "clo" in clocapramine refers to the chlorine atom in its structure, while "capramine" is a common suffix used in the names of antipsychotic medications.

Pharmacology

Clocapramine acts as an antagonist at several receptors in the brain, including dopamine receptors, serotonin receptors, and adrenergic receptors. It has a high affinity for the D2 and D3 dopamine receptors, which are thought to be involved in the pathophysiology of schizophrenia. Clocapramine also has a high affinity for the 5-HT2A and 5-HT2C serotonin receptors, which may contribute to its efficacy in treating anxiety and mood disorders.

Side Effects

Like all antipsychotic medications, clocapramine can cause a range of side effects. These can include drowsiness, dizziness, dry mouth, constipation, and weight gain. In rare cases, clocapramine can cause more serious side effects such as tardive dyskinesia, a condition characterized by involuntary movements of the face and body.

Related Terms

• Antipsychotic
• Dibenzazepine
• Schizophrenia
• Anxiety disorder
• Mood disorder
• Receptor (biochemistry)
• Dopamine receptor
• Serotonin receptor
• Adrenergic receptor
• Tardive dyskinesia

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