Centroacinar cell

Centroacinar Cell

Centroacinar cells in the pancreas

Centroacinar cells are specialized cells located in the pancreas, specifically within the exocrine pancreas. These cells are an integral part of the pancreatic ductal system and play a crucial role in the secretion of bicarbonate and other components of the pancreatic juice.

Structure

Centroacinar cells are found at the junction of the pancreatic acini and the intercalated ducts. They are characterized by their small size and pale-staining cytoplasm. These cells are unique to the pancreas and are not found in other exocrine glands.

Function

The primary function of centroacinar cells is to secrete bicarbonate-rich fluid, which helps to neutralize the acidic chyme entering the duodenum from the stomach. This secretion is essential for creating an optimal pH environment for the activity of pancreatic enzymes.

Role in Pancreatic Secretion

Centroacinar cells, along with the ductal cells, contribute to the production of the aqueous component of pancreatic juice. This process is regulated by the hormone secretin, which stimulates the secretion of bicarbonate in response to acidic chyme in the duodenum.

Clinical Significance

Dysfunction or damage to centroacinar cells can affect pancreatic secretion and may contribute to conditions such as pancreatitis. Understanding the role of these cells is important in the study of pancreatic diseases and their treatment.

Related Pages

• Pancreas
• Pancreatic duct
• Exocrine gland
• Bicarbonate
• Secretin