Secretin

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Secretin

Secretin (/sɪˈkriːtɪn/) is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the crypts of Lieberkühn.

Etymology

The term "secretin" derives from the Latin secretio, meaning "separation". It was named by the English physiologists William Bayliss and Ernest Starling in 1902, who discovered it during their research on the nervous control of the secretory activity of the pancreas.

Function

Secretin primarily functions to neutralize the acidic chyme entering the duodenum from the stomach. It promotes the release of bicarbonate from the pancreas to act as a buffer, and also inhibits the secretion of gastrin and gastric acid from the stomach. Furthermore, secretin stimulates the secretion of water and bicarbonate from the liver into the bile, aiding in the creation of an optimal intestinal environment.

Related Terms

  • Cholecystokinin: A hormone that aids digestion and reduces appetite.
  • Gastrin: A hormone that stimulates the production of gastric acid.
  • Ghrelin: A hormone that stimulates hunger.
  • Peptide hormone: A hormone made of amino acids.
  • Crypts of Lieberkühn: Glandular simple tubular structures in the lining of the small intestine and colon.

See Also

External links

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