Giant-cell tumor of bone: Difference between revisions
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{{Infobox medical condition | |||
| name = Giant-cell tumor of bone | |||
| image = [[File:Giant_cell_tumour_of_bone_-_high_mag.jpg|left|thumb|Micrograph of a giant-cell tumor of bone. H&E stain.]] | |||
| caption = Micrograph of a giant-cell tumor of bone. H&E stain. | |||
| field = [[Oncology]], [[Orthopedic surgery]] | |||
| synonyms = Osteoclastoma | |||
| symptoms = [[Pain]], [[swelling]], [[limited range of motion]] | |||
| complications = [[Pathologic fracture]], [[metastasis]] | |||
| onset = Typically between ages 20 and 40 | |||
| duration = Variable | |||
| causes = Unknown | |||
| risks = [[Paget's disease of bone]], [[radiation therapy]] | |||
| diagnosis = [[X-ray]], [[MRI]], [[biopsy]] | |||
| differential = [[Aneurysmal bone cyst]], [[chondroblastoma]], [[osteosarcoma]] | |||
| treatment = [[Surgery]], [[radiation therapy]], [[denosumab]] | |||
| prognosis = Generally good with treatment | |||
| frequency = 5% of all primary bone tumors | |||
}} | |||
[[File:Giant_cell_tumour_of_bone_-_very_high_mag.jpg|Giant-cell tumor of bone - very high magnification|thumb]] | |||
[[File:Giant_cell_tumor_of_bone08.JPG|Giant-cell tumor of bone|thumb|left]] | |||
'''Giant-cell tumor of bone''' ('''GCTOB''') is a relatively uncommon tumor of the bone. It is characterized by the presence of multinucleated giant cells. These tumors are generally benign. However, they can be locally aggressive and may recur after surgery. | '''Giant-cell tumor of bone''' ('''GCTOB''') is a relatively uncommon tumor of the bone. It is characterized by the presence of multinucleated giant cells. These tumors are generally benign. However, they can be locally aggressive and may recur after surgery. | ||
==Epidemiology== | ==Epidemiology== | ||
GCTOB accounts for about 5% of all primary bone tumors. It usually occurs in adults between the ages of 20 and 40. It is slightly more common in women than in men. | GCTOB accounts for about 5% of all primary bone tumors. It usually occurs in adults between the ages of 20 and 40. It is slightly more common in women than in men. | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
Patients with GCTOB often present with pain and swelling in the affected bone. The tumor most commonly affects the long bones, particularly the distal femur, proximal tibia, and distal radius. | Patients with GCTOB often present with pain and swelling in the affected bone. The tumor most commonly affects the long bones, particularly the distal femur, proximal tibia, and distal radius. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of GCTOB is usually made based on the clinical presentation, radiographic findings, and histological examination of the tumor. Radiographs typically show a lytic, expansile lesion with a narrow zone of transition. Histologically, the tumor is composed of a mixture of mononuclear stromal cells and multinucleated giant cells. | The diagnosis of GCTOB is usually made based on the clinical presentation, radiographic findings, and histological examination of the tumor. Radiographs typically show a lytic, expansile lesion with a narrow zone of transition. Histologically, the tumor is composed of a mixture of mononuclear stromal cells and multinucleated giant cells. | ||
==Treatment== | ==Treatment== | ||
The treatment of GCTOB typically involves surgery to remove the tumor. In some cases, adjuvant therapy with radiation or medications may be used to reduce the risk of recurrence. | The treatment of GCTOB typically involves surgery to remove the tumor. In some cases, adjuvant therapy with radiation or medications may be used to reduce the risk of recurrence. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for patients with GCTOB is generally good. However, the tumor can be locally aggressive and may recur after surgery. In rare cases, GCTOB can metastasize to the lungs. | The prognosis for patients with GCTOB is generally good. However, the tumor can be locally aggressive and may recur after surgery. In rare cases, GCTOB can metastasize to the lungs. | ||
[[Category:Bone tumors]] | [[Category:Bone tumors]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Orthopedics]] | [[Category:Orthopedics]] | ||
See also: | See also: | ||
* [[Bone tumor]] | * [[Bone tumor]] | ||
| Line 25: | Line 39: | ||
* [[Chondrosarcoma]] | * [[Chondrosarcoma]] | ||
* [[Ewing's sarcoma]] | * [[Ewing's sarcoma]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 21:22, 9 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Giant-cell tumor of bone | |
|---|---|
| Synonyms | Osteoclastoma |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Pain, swelling, limited range of motion |
| Complications | Pathologic fracture, metastasis |
| Onset | Typically between ages 20 and 40 |
| Duration | Variable |
| Types | N/A |
| Causes | Unknown |
| Risks | Paget's disease of bone, radiation therapy |
| Diagnosis | X-ray, MRI, biopsy |
| Differential diagnosis | Aneurysmal bone cyst, chondroblastoma, osteosarcoma |
| Prevention | N/A |
| Treatment | Surgery, radiation therapy, denosumab |
| Medication | N/A |
| Prognosis | Generally good with treatment |
| Frequency | 5% of all primary bone tumors |
| Deaths | N/A |
Giant-cell tumor of bone (GCTOB) is a relatively uncommon tumor of the bone. It is characterized by the presence of multinucleated giant cells. These tumors are generally benign. However, they can be locally aggressive and may recur after surgery.
Epidemiology[edit]
GCTOB accounts for about 5% of all primary bone tumors. It usually occurs in adults between the ages of 20 and 40. It is slightly more common in women than in men.
Clinical Presentation[edit]
Patients with GCTOB often present with pain and swelling in the affected bone. The tumor most commonly affects the long bones, particularly the distal femur, proximal tibia, and distal radius.
Diagnosis[edit]
The diagnosis of GCTOB is usually made based on the clinical presentation, radiographic findings, and histological examination of the tumor. Radiographs typically show a lytic, expansile lesion with a narrow zone of transition. Histologically, the tumor is composed of a mixture of mononuclear stromal cells and multinucleated giant cells.
Treatment[edit]
The treatment of GCTOB typically involves surgery to remove the tumor. In some cases, adjuvant therapy with radiation or medications may be used to reduce the risk of recurrence.
Prognosis[edit]
The prognosis for patients with GCTOB is generally good. However, the tumor can be locally aggressive and may recur after surgery. In rare cases, GCTOB can metastasize to the lungs. See also:
