Pagetoid reticulosis: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{SI}} | |||
{{Infobox medical condition | |||
| name = Pagetoid reticulosis | |||
| image = [[File:SkinTumors-PC181140.jpg|left|thumb|Pagetoid reticulosis]] | |||
| caption = Skin manifestation of Pagetoid reticulosis | |||
| field = [[Dermatology]], [[Oncology]] | |||
| synonyms = Woringer-Kolopp disease | |||
| symptoms = [[Skin lesions]], [[erythematous]] patches | |||
| complications = Potential progression to [[cutaneous T-cell lymphoma]] | |||
| onset = Typically in [[adulthood]] | |||
| duration = Chronic | |||
| causes = Unknown | |||
| risks = [[Immunosuppression]], [[genetic predisposition]] | |||
| diagnosis = [[Skin biopsy]], [[histopathology]] | |||
| differential = [[Mycosis fungoides]], [[Paget's disease of the breast]] | |||
| treatment = [[Radiation therapy]], [[topical corticosteroids]] | |||
| prognosis = Generally good with treatment | |||
| frequency = Rare | |||
}} | |||
{{Short description|A rare form of cutaneous T-cell lymphoma}} | {{Short description|A rare form of cutaneous T-cell lymphoma}} | ||
Pagetoid reticulosis is a rare form of [[cutaneous T-cell lymphoma]] characterized by the presence of localized patches or plaques on the skin. It is considered a variant of [[mycosis fungoides]], which is the most common type of cutaneous T-cell lymphoma. | Pagetoid reticulosis is a rare form of [[cutaneous T-cell lymphoma]] characterized by the presence of localized patches or plaques on the skin. It is considered a variant of [[mycosis fungoides]], which is the most common type of cutaneous T-cell lymphoma. | ||
=== Clinical Presentation === | === Clinical Presentation === | ||
Pagetoid reticulosis typically presents as a solitary lesion, often on the extremities. The lesion is usually a well-demarcated, scaly plaque that may be mistaken for other dermatological conditions such as [[psoriasis]] or [[eczema]]. Unlike mycosis fungoides, pagetoid reticulosis does not typically progress to involve other areas of the skin or internal organs. | Pagetoid reticulosis typically presents as a solitary lesion, often on the extremities. The lesion is usually a well-demarcated, scaly plaque that may be mistaken for other dermatological conditions such as [[psoriasis]] or [[eczema]]. Unlike mycosis fungoides, pagetoid reticulosis does not typically progress to involve other areas of the skin or internal organs. | ||
=== Histopathology === | === Histopathology === | ||
The histological hallmark of pagetoid reticulosis is the presence of atypical T-cells with a pagetoid spread within the epidermis. This means that the atypical cells are scattered throughout the epidermis in a pattern reminiscent of [[Paget's disease of the breast]]. The cells are often CD4 positive, and immunohistochemical staining is used to confirm the diagnosis. | The histological hallmark of pagetoid reticulosis is the presence of atypical T-cells with a pagetoid spread within the epidermis. This means that the atypical cells are scattered throughout the epidermis in a pattern reminiscent of [[Paget's disease of the breast]]. The cells are often CD4 positive, and immunohistochemical staining is used to confirm the diagnosis. | ||
=== Diagnosis === | === Diagnosis === | ||
Diagnosis of pagetoid reticulosis is based on clinical examination, histopathological analysis, and immunophenotyping. A skin biopsy is essential to observe the characteristic histological features. Differential diagnosis includes other forms of cutaneous T-cell lymphoma, [[Bowen's disease]], and [[extramammary Paget's disease]]. | Diagnosis of pagetoid reticulosis is based on clinical examination, histopathological analysis, and immunophenotyping. A skin biopsy is essential to observe the characteristic histological features. Differential diagnosis includes other forms of cutaneous T-cell lymphoma, [[Bowen's disease]], and [[extramammary Paget's disease]]. | ||
=== Treatment === | === Treatment === | ||
Treatment options for pagetoid reticulosis are generally localized due to its indolent nature. These may include: | Treatment options for pagetoid reticulosis are generally localized due to its indolent nature. These may include: | ||
| Line 21: | Line 32: | ||
* Localized radiation therapy | * Localized radiation therapy | ||
* Surgical excision | * Surgical excision | ||
In most cases, the prognosis is excellent, with a low risk of progression or systemic involvement. | In most cases, the prognosis is excellent, with a low risk of progression or systemic involvement. | ||
== See also == | |||
== | |||
* [[Mycosis fungoides]] | * [[Mycosis fungoides]] | ||
* [[Cutaneous T-cell lymphoma]] | * [[Cutaneous T-cell lymphoma]] | ||
* [[Paget's disease of the breast]] | * [[Paget's disease of the breast]] | ||
* [[Psoriasis]] | * [[Psoriasis]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Lymphoma]] | [[Category:Lymphoma]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
Latest revision as of 15:38, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Pagetoid reticulosis | |
|---|---|
 | |
| Synonyms | Woringer-Kolopp disease |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Skin lesions, erythematous patches |
| Complications | Potential progression to cutaneous T-cell lymphoma |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Unknown |
| Risks | Immunosuppression, genetic predisposition |
| Diagnosis | Skin biopsy, histopathology |
| Differential diagnosis | Mycosis fungoides, Paget's disease of the breast |
| Prevention | N/A |
| Treatment | Radiation therapy, topical corticosteroids |
| Medication | N/A |
| Prognosis | Generally good with treatment |
| Frequency | Rare |
| Deaths | N/A |
A rare form of cutaneous T-cell lymphoma
Pagetoid reticulosis is a rare form of cutaneous T-cell lymphoma characterized by the presence of localized patches or plaques on the skin. It is considered a variant of mycosis fungoides, which is the most common type of cutaneous T-cell lymphoma.
Clinical Presentation[edit]
Pagetoid reticulosis typically presents as a solitary lesion, often on the extremities. The lesion is usually a well-demarcated, scaly plaque that may be mistaken for other dermatological conditions such as psoriasis or eczema. Unlike mycosis fungoides, pagetoid reticulosis does not typically progress to involve other areas of the skin or internal organs.
Histopathology[edit]
The histological hallmark of pagetoid reticulosis is the presence of atypical T-cells with a pagetoid spread within the epidermis. This means that the atypical cells are scattered throughout the epidermis in a pattern reminiscent of Paget's disease of the breast. The cells are often CD4 positive, and immunohistochemical staining is used to confirm the diagnosis.
Diagnosis[edit]
Diagnosis of pagetoid reticulosis is based on clinical examination, histopathological analysis, and immunophenotyping. A skin biopsy is essential to observe the characteristic histological features. Differential diagnosis includes other forms of cutaneous T-cell lymphoma, Bowen's disease, and extramammary Paget's disease.
Treatment[edit]
Treatment options for pagetoid reticulosis are generally localized due to its indolent nature. These may include:
- Topical corticosteroids
- Phototherapy
- Localized radiation therapy
- Surgical excision
In most cases, the prognosis is excellent, with a low risk of progression or systemic involvement.
