Linear verrucous epidermal nevus: Difference between revisions
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{{Infobox medical condition | |||
| name = Linear verrucous epidermal nevus | |||
| image = [[File:SkinTumors-P5280048.JPG|left|thumb|Linear verrucous epidermal nevus]] | |||
| caption = Linear verrucous epidermal nevus on the skin | |||
| synonyms = Verrucous epidermal nevus | |||
| field = [[Dermatology]] | |||
| symptoms = [[Wart]]-like lesions, [[hyperkeratosis]], [[pruritus]] | |||
| complications = [[Secondary infection]], [[malignant transformation]] | |||
| onset = [[Childhood]] | |||
| duration = [[Chronic (medicine)|Chronic]] | |||
| causes = [[Genetic mutation]] | |||
| risks = [[Genetic predisposition]] | |||
| diagnosis = [[Clinical diagnosis]], [[skin biopsy]] | |||
| differential = [[Verrucous carcinoma]], [[psoriasis]], [[lichen planus]] | |||
| treatment = [[Topical treatment]], [[surgical excision]], [[laser therapy]] | |||
| medication = [[Keratolytics]], [[retinoids]] | |||
| frequency = Rare | |||
}} | |||
{{Short description|A type of skin lesion}} | {{Short description|A type of skin lesion}} | ||
'''Linear verrucous epidermal nevus''' (LVEN) is a type of [[epidermal nevus]] characterized by a linear arrangement of [[verrucous]] skin lesions. These lesions are typically present at birth or develop in early childhood and are caused by a genetic mosaicism. | '''Linear verrucous epidermal nevus''' (LVEN) is a type of [[epidermal nevus]] characterized by a linear arrangement of [[verrucous]] skin lesions. These lesions are typically present at birth or develop in early childhood and are caused by a genetic mosaicism. | ||
==Presentation== | ==Presentation== | ||
Linear verrucous epidermal nevus presents as a series of [[hyperkeratotic]] and [[verrucous]] papules that coalesce into linear plaques. These lesions follow the lines of [[Blaschko's lines]], which are patterns of skin cell development. The lesions are often [[hyperpigmented]] and can vary in color from light brown to dark brown or black. | Linear verrucous epidermal nevus presents as a series of [[hyperkeratotic]] and [[verrucous]] papules that coalesce into linear plaques. These lesions follow the lines of [[Blaschko's lines]], which are patterns of skin cell development. The lesions are often [[hyperpigmented]] and can vary in color from light brown to dark brown or black. | ||
==Pathophysiology== | ==Pathophysiology== | ||
LVEN is caused by a postzygotic mutation leading to genetic mosaicism. This results in a localized area of skin cells that proliferate abnormally, forming the characteristic lesions. The exact genetic mutations involved can vary, but they often affect genes related to skin cell growth and differentiation. | LVEN is caused by a postzygotic mutation leading to genetic mosaicism. This results in a localized area of skin cells that proliferate abnormally, forming the characteristic lesions. The exact genetic mutations involved can vary, but they often affect genes related to skin cell growth and differentiation. | ||
==Diagnosis== | ==Diagnosis== | ||
Diagnosis of linear verrucous epidermal nevus is primarily clinical, based on the appearance and distribution of the lesions. A [[skin biopsy]] may be performed to confirm the diagnosis and rule out other conditions. Histologically, the lesions show [[acanthosis]], [[hyperkeratosis]], and papillomatosis. | Diagnosis of linear verrucous epidermal nevus is primarily clinical, based on the appearance and distribution of the lesions. A [[skin biopsy]] may be performed to confirm the diagnosis and rule out other conditions. Histologically, the lesions show [[acanthosis]], [[hyperkeratosis]], and papillomatosis. | ||
==Management== | ==Management== | ||
Management of LVEN is often conservative, as the lesions are benign. However, treatment may be sought for cosmetic reasons or if the lesions become symptomatic. Options include: | Management of LVEN is often conservative, as the lesions are benign. However, treatment may be sought for cosmetic reasons or if the lesions become symptomatic. Options include: | ||
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* [[Laser therapy]] | * [[Laser therapy]] | ||
* [[Surgical excision]] | * [[Surgical excision]] | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for individuals with linear verrucous epidermal nevus is generally good, as the condition is benign. However, there is a small risk of [[malignant transformation]] in long-standing lesions, so regular monitoring is recommended. | The prognosis for individuals with linear verrucous epidermal nevus is generally good, as the condition is benign. However, there is a small risk of [[malignant transformation]] in long-standing lesions, so regular monitoring is recommended. | ||
==See also== | |||
== | |||
* [[Epidermal nevus]] | * [[Epidermal nevus]] | ||
* [[Blaschko's lines]] | * [[Blaschko's lines]] | ||
* [[Genetic mosaicism]] | * [[Genetic mosaicism]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Skin conditions resulting in tumors]] | [[Category:Skin conditions resulting in tumors]] | ||
Latest revision as of 01:13, 8 April 2025
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| Linear verrucous epidermal nevus | |
|---|---|
 | |
| Synonyms | Verrucous epidermal nevus |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Wart-like lesions, hyperkeratosis, pruritus |
| Complications | Secondary infection, malignant transformation |
| Onset | Childhood |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic mutation |
| Risks | Genetic predisposition |
| Diagnosis | Clinical diagnosis, skin biopsy |
| Differential diagnosis | Verrucous carcinoma, psoriasis, lichen planus |
| Prevention | N/A |
| Treatment | Topical treatment, surgical excision, laser therapy |
| Medication | Keratolytics, retinoids |
| Prognosis | N/A |
| Frequency | Rare |
| Deaths | N/A |
A type of skin lesion
Linear verrucous epidermal nevus (LVEN) is a type of epidermal nevus characterized by a linear arrangement of verrucous skin lesions. These lesions are typically present at birth or develop in early childhood and are caused by a genetic mosaicism.
Presentation[edit]
Linear verrucous epidermal nevus presents as a series of hyperkeratotic and verrucous papules that coalesce into linear plaques. These lesions follow the lines of Blaschko's lines, which are patterns of skin cell development. The lesions are often hyperpigmented and can vary in color from light brown to dark brown or black.
Pathophysiology[edit]
LVEN is caused by a postzygotic mutation leading to genetic mosaicism. This results in a localized area of skin cells that proliferate abnormally, forming the characteristic lesions. The exact genetic mutations involved can vary, but they often affect genes related to skin cell growth and differentiation.
Diagnosis[edit]
Diagnosis of linear verrucous epidermal nevus is primarily clinical, based on the appearance and distribution of the lesions. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions. Histologically, the lesions show acanthosis, hyperkeratosis, and papillomatosis.
Management[edit]
Management of LVEN is often conservative, as the lesions are benign. However, treatment may be sought for cosmetic reasons or if the lesions become symptomatic. Options include:
Prognosis[edit]
The prognosis for individuals with linear verrucous epidermal nevus is generally good, as the condition is benign. However, there is a small risk of malignant transformation in long-standing lesions, so regular monitoring is recommended.
