Granular cell tumor: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{SI}} | |||
{{Infobox medical condition | |||
| name = Granular cell tumor | |||
| image = [[File:Granular_Cell_Tumor.jpg|left|thumb|Granular cell tumor]] | |||
| caption = Histopathological image of a granular cell tumor | |||
| field = [[Oncology]] | |||
| synonyms = Abrikossoff's tumor | |||
| symptoms = Usually asymptomatic, may present as a painless nodule | |||
| complications = Rarely [[malignant transformation]] | |||
| onset = Can occur at any age, most common in adults | |||
| duration = Persistent unless surgically removed | |||
| causes = Unknown | |||
| risks = [[Neurofibromatosis]], [[African American]] ethnicity | |||
| diagnosis = [[Biopsy]] and [[histopathology]] | |||
| differential = [[Schwannoma]], [[lipoma]], [[neurofibroma]] | |||
| prevention = None known | |||
| treatment = [[Surgical excision]] | |||
| medication = None specific | |||
| prognosis = Excellent if benign, guarded if malignant | |||
| frequency = Rare | |||
}} | |||
'''Granular cell tumor''' is a type of [[neoplasm]] that is typically benign, but can occasionally be malignant. It is characterized by the presence of large cells with granular cytoplasm. These tumors can occur anywhere in the body, but are most commonly found in the skin, oral cavity, and breast. | '''Granular cell tumor''' is a type of [[neoplasm]] that is typically benign, but can occasionally be malignant. It is characterized by the presence of large cells with granular cytoplasm. These tumors can occur anywhere in the body, but are most commonly found in the skin, oral cavity, and breast. | ||
==Etiology== | ==Etiology== | ||
The exact cause of granular cell tumors is unknown. However, they are believed to originate from [[Schwann cells]], which are cells that produce the protective myelin sheath covering nerve fibers. | The exact cause of granular cell tumors is unknown. However, they are believed to originate from [[Schwann cells]], which are cells that produce the protective myelin sheath covering nerve fibers. | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
Granular cell tumors typically present as painless, firm nodules that are less than 3 cm in diameter. They can occur at any age, but are most common in middle-aged adults. There is a slight female predominance, and they are more common in people of African descent. | Granular cell tumors typically present as painless, firm nodules that are less than 3 cm in diameter. They can occur at any age, but are most common in middle-aged adults. There is a slight female predominance, and they are more common in people of African descent. | ||
==Diagnosis== | ==Diagnosis== | ||
Diagnosis of a granular cell tumor is typically made through a [[biopsy]] of the lesion. Histologically, the tumor cells are large and polygonal, with abundant granular eosinophilic cytoplasm. The granules are positive for [[Periodic acid-Schiff]] (PAS) staining, which is indicative of the presence of lysosomes. | Diagnosis of a granular cell tumor is typically made through a [[biopsy]] of the lesion. Histologically, the tumor cells are large and polygonal, with abundant granular eosinophilic cytoplasm. The granules are positive for [[Periodic acid-Schiff]] (PAS) staining, which is indicative of the presence of lysosomes. | ||
==Treatment== | ==Treatment== | ||
Treatment for granular cell tumors typically involves surgical excision. In cases where the tumor is malignant, additional treatments such as [[radiation therapy]] or [[chemotherapy]] may be necessary. | Treatment for granular cell tumors typically involves surgical excision. In cases where the tumor is malignant, additional treatments such as [[radiation therapy]] or [[chemotherapy]] may be necessary. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for individuals with granular cell tumors is generally good, as the majority of these tumors are benign. However, malignant granular cell tumors can be aggressive and have a poorer prognosis. | The prognosis for individuals with granular cell tumors is generally good, as the majority of these tumors are benign. However, malignant granular cell tumors can be aggressive and have a poorer prognosis. | ||
==See Also== | ==See Also== | ||
* [[Neoplasm]] | * [[Neoplasm]] | ||
* [[Schwann cell]] | * [[Schwann cell]] | ||
| Line 29: | Line 38: | ||
* [[Radiation therapy]] | * [[Radiation therapy]] | ||
* [[Chemotherapy]] | * [[Chemotherapy]] | ||
[[Category:Neoplasms]] | [[Category:Neoplasms]] | ||
[[Category:Pathology]] | [[Category:Pathology]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 20:17, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Granular cell tumor | |
|---|---|
 | |
| Synonyms | Abrikossoff's tumor |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Usually asymptomatic, may present as a painless nodule |
| Complications | Rarely malignant transformation |
| Onset | Can occur at any age, most common in adults |
| Duration | Persistent unless surgically removed |
| Types | N/A |
| Causes | Unknown |
| Risks | Neurofibromatosis, African American ethnicity |
| Diagnosis | Biopsy and histopathology |
| Differential diagnosis | Schwannoma, lipoma, neurofibroma |
| Prevention | None known |
| Treatment | Surgical excision |
| Medication | None specific |
| Prognosis | Excellent if benign, guarded if malignant |
| Frequency | Rare |
| Deaths | N/A |
Granular cell tumor is a type of neoplasm that is typically benign, but can occasionally be malignant. It is characterized by the presence of large cells with granular cytoplasm. These tumors can occur anywhere in the body, but are most commonly found in the skin, oral cavity, and breast.
Etiology[edit]
The exact cause of granular cell tumors is unknown. However, they are believed to originate from Schwann cells, which are cells that produce the protective myelin sheath covering nerve fibers.
Clinical Presentation[edit]
Granular cell tumors typically present as painless, firm nodules that are less than 3 cm in diameter. They can occur at any age, but are most common in middle-aged adults. There is a slight female predominance, and they are more common in people of African descent.
Diagnosis[edit]
Diagnosis of a granular cell tumor is typically made through a biopsy of the lesion. Histologically, the tumor cells are large and polygonal, with abundant granular eosinophilic cytoplasm. The granules are positive for Periodic acid-Schiff (PAS) staining, which is indicative of the presence of lysosomes.
Treatment[edit]
Treatment for granular cell tumors typically involves surgical excision. In cases where the tumor is malignant, additional treatments such as radiation therapy or chemotherapy may be necessary.
Prognosis[edit]
The prognosis for individuals with granular cell tumors is generally good, as the majority of these tumors are benign. However, malignant granular cell tumors can be aggressive and have a poorer prognosis.
