Primary cutaneous coccidioidomycosis: Difference between revisions
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{{Infobox medical condition | |||
| name = Primary cutaneous coccidioidomycosis | |||
| image = [[File:Coccidiodes_lesion_1.jpg|thumb|Lesion caused by ''Coccidioides'' infection]] | |||
| caption = Lesion caused by ''Coccidioides'' infection | |||
| field = [[Infectious disease]] | |||
| synonyms = | |||
| symptoms = Skin lesions, [[erythema]], [[ulceration]] | |||
| complications = [[Disseminated coccidioidomycosis]] | |||
| onset = | |||
| duration = | |||
| causes = ''[[Coccidioides immitis]]'' or ''[[Coccidioides posadasii]]'' | |||
| risks = Exposure to [[soil]] in endemic areas | |||
| diagnosis = [[Skin biopsy]], [[culture]], [[serology]] | |||
| differential = [[Pyoderma gangrenosum]], [[cutaneous leishmaniasis]] | |||
| prevention = Avoidance of soil exposure in endemic areas | |||
| treatment = [[Antifungal]] medications such as [[fluconazole]] or [[itraconazole]] | |||
| medication = | |||
| prognosis = Generally good with treatment | |||
| frequency = Rare | |||
| deaths = | |||
}} | |||
'''Primary cutaneous coccidioidomycosis''' is a rare form of [[coccidioidomycosis]], a fungal infection caused by the [[Coccidioides]] species. This form of the disease is characterized by skin lesions that occur following direct inoculation of the fungus into the skin, without any evidence of pulmonary or systemic involvement. | '''Primary cutaneous coccidioidomycosis''' is a rare form of [[coccidioidomycosis]], a fungal infection caused by the [[Coccidioides]] species. This form of the disease is characterized by skin lesions that occur following direct inoculation of the fungus into the skin, without any evidence of pulmonary or systemic involvement. | ||
==Etiology== | ==Etiology== | ||
Primary cutaneous coccidioidomycosis is caused by two species of fungi, [[Coccidioides immitis]] and [[Coccidioides posadasii]]. These fungi are endemic to the southwestern United States, northern Mexico, and parts of Central and South America. They reside in the soil and are released into the air when the soil is disturbed, leading to inhalation and potential infection. | Primary cutaneous coccidioidomycosis is caused by two species of fungi, [[Coccidioides immitis]] and [[Coccidioides posadasii]]. These fungi are endemic to the southwestern United States, northern Mexico, and parts of Central and South America. They reside in the soil and are released into the air when the soil is disturbed, leading to inhalation and potential infection. | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
The disease typically presents as a solitary skin lesion at the site of inoculation. The lesion may initially appear as a small, erythematous papule that gradually enlarges and may ulcerate. Over time, the lesion may develop a verrucous or nodular appearance. The lesion is often accompanied by regional lymphadenopathy. | The disease typically presents as a solitary skin lesion at the site of inoculation. The lesion may initially appear as a small, erythematous papule that gradually enlarges and may ulcerate. Over time, the lesion may develop a verrucous or nodular appearance. The lesion is often accompanied by regional lymphadenopathy. | ||
==Diagnosis== | ==Diagnosis== | ||
Diagnosis of primary cutaneous coccidioidomycosis is typically made through a combination of clinical presentation, histopathological examination of a skin biopsy, and culture of the organism. The [[histopathology]] often reveals granulomatous inflammation with multinucleated giant cells and spherules filled with endospores, characteristic of Coccidioides infection. | Diagnosis of primary cutaneous coccidioidomycosis is typically made through a combination of clinical presentation, histopathological examination of a skin biopsy, and culture of the organism. The [[histopathology]] often reveals granulomatous inflammation with multinucleated giant cells and spherules filled with endospores, characteristic of Coccidioides infection. | ||
==Treatment== | ==Treatment== | ||
Treatment typically involves antifungal medications, such as [[fluconazole]] or [[itraconazole]]. In severe cases, or in individuals with compromised immune systems, amphotericin B may be used. | Treatment typically involves antifungal medications, such as [[fluconazole]] or [[itraconazole]]. In severe cases, or in individuals with compromised immune systems, amphotericin B may be used. | ||
==Epidemiology== | ==Epidemiology== | ||
Primary cutaneous coccidioidomycosis is a rare form of coccidioidomycosis. It is most commonly seen in individuals who live in or have traveled to endemic areas and have had direct skin contact with the soil or dust. | Primary cutaneous coccidioidomycosis is a rare form of coccidioidomycosis. It is most commonly seen in individuals who live in or have traveled to endemic areas and have had direct skin contact with the soil or dust. | ||
==See Also== | ==See Also== | ||
* [[Coccidioidomycosis]] | * [[Coccidioidomycosis]] | ||
* [[Coccidioides immitis]] | * [[Coccidioides immitis]] | ||
* [[Coccidioides posadasii]] | * [[Coccidioides posadasii]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Infectious diseases]] | [[Category:Infectious diseases]] | ||
| Line 32: | Line 41: | ||
{{Dermatology-stub}} | {{Dermatology-stub}} | ||
{{Infectious-disease-stub}} | {{Infectious-disease-stub}} | ||
Latest revision as of 05:42, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
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| Primary cutaneous coccidioidomycosis | |
|---|---|
 | |
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Skin lesions, erythema, ulceration |
| Complications | Disseminated coccidioidomycosis |
| Onset | |
| Duration | |
| Types | N/A |
| Causes | Coccidioides immitis or Coccidioides posadasii |
| Risks | Exposure to soil in endemic areas |
| Diagnosis | Skin biopsy, culture, serology |
| Differential diagnosis | Pyoderma gangrenosum, cutaneous leishmaniasis |
| Prevention | Avoidance of soil exposure in endemic areas |
| Treatment | Antifungal medications such as fluconazole or itraconazole |
| Medication | |
| Prognosis | Generally good with treatment |
| Frequency | Rare |
| Deaths | |
Primary cutaneous coccidioidomycosis is a rare form of coccidioidomycosis, a fungal infection caused by the Coccidioides species. This form of the disease is characterized by skin lesions that occur following direct inoculation of the fungus into the skin, without any evidence of pulmonary or systemic involvement.
Etiology[edit]
Primary cutaneous coccidioidomycosis is caused by two species of fungi, Coccidioides immitis and Coccidioides posadasii. These fungi are endemic to the southwestern United States, northern Mexico, and parts of Central and South America. They reside in the soil and are released into the air when the soil is disturbed, leading to inhalation and potential infection.
Clinical Presentation[edit]
The disease typically presents as a solitary skin lesion at the site of inoculation. The lesion may initially appear as a small, erythematous papule that gradually enlarges and may ulcerate. Over time, the lesion may develop a verrucous or nodular appearance. The lesion is often accompanied by regional lymphadenopathy.
Diagnosis[edit]
Diagnosis of primary cutaneous coccidioidomycosis is typically made through a combination of clinical presentation, histopathological examination of a skin biopsy, and culture of the organism. The histopathology often reveals granulomatous inflammation with multinucleated giant cells and spherules filled with endospores, characteristic of Coccidioides infection.
Treatment[edit]
Treatment typically involves antifungal medications, such as fluconazole or itraconazole. In severe cases, or in individuals with compromised immune systems, amphotericin B may be used.
Epidemiology[edit]
Primary cutaneous coccidioidomycosis is a rare form of coccidioidomycosis. It is most commonly seen in individuals who live in or have traveled to endemic areas and have had direct skin contact with the soil or dust.
See Also[edit]
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This article is a infectious disease stub. You can help WikiMD by expanding it!
