Lymphomatoid granulomatosis: Difference between revisions
No edit summary Tag: Manual revert |
CSV import |
||
| Line 1: | Line 1: | ||
{{Infobox medical condition | |||
| name = Lymphomatoid granulomatosis | |||
| synonyms = | |||
| field = [[Hematology]], [[Oncology]] | |||
| symptoms = [[Fever]], [[cough]], [[shortness of breath]], [[skin lesions]] | |||
| complications = [[Pulmonary nodules]], [[central nervous system involvement]] | |||
| onset = | |||
| duration = | |||
| types = | |||
| causes = [[Epstein-Barr virus]] infection | |||
| risks = [[Immunosuppression]], [[HIV/AIDS]], [[organ transplantation]] | |||
| diagnosis = [[Biopsy]], [[imaging studies]] | |||
| differential = [[Wegener's granulomatosis]], [[sarcoidosis]], [[lymphoma]] | |||
| prevention = | |||
| treatment = [[Chemotherapy]], [[immunotherapy]], [[corticosteroids]] | |||
| medication = | |||
| prognosis = Variable, depends on stage and response to treatment | |||
| frequency = Rare | |||
}} | |||
'''Lymphomatoid granulomatosis''' (also known as '''LYG''' or '''LG''') is a rare [[lymphoproliferative disorder]] characterized by [[lymphoma]]-like symptoms. It is associated with [[Epstein-Barr virus]] (EBV) infection and is considered a form of [[angiocentric lymphoma]]. | '''Lymphomatoid granulomatosis''' (also known as '''LYG''' or '''LG''') is a rare [[lymphoproliferative disorder]] characterized by [[lymphoma]]-like symptoms. It is associated with [[Epstein-Barr virus]] (EBV) infection and is considered a form of [[angiocentric lymphoma]]. | ||
==Epidemiology== | ==Epidemiology== | ||
Lymphomatoid granulomatosis is a rare disease, with an estimated incidence of less than 1 in 1,000,000. It affects both sexes equally and can occur at any age, although it is most common in middle-aged adults. | Lymphomatoid granulomatosis is a rare disease, with an estimated incidence of less than 1 in 1,000,000. It affects both sexes equally and can occur at any age, although it is most common in middle-aged adults. | ||
==Pathophysiology== | ==Pathophysiology== | ||
The disease is characterized by an abnormal proliferation of [[B cells]] that are infected with the Epstein-Barr virus. These cells infiltrate the [[lung]]s, [[skin]], [[kidney]], [[central nervous system]] and other organs, causing inflammation and damage. | The disease is characterized by an abnormal proliferation of [[B cells]] that are infected with the Epstein-Barr virus. These cells infiltrate the [[lung]]s, [[skin]], [[kidney]], [[central nervous system]] and other organs, causing inflammation and damage. | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
Patients with lymphomatoid granulomatosis typically present with nonspecific symptoms such as [[fever]], [[weight loss]], [[cough]], and [[shortness of breath]]. Skin lesions, neurological symptoms, and kidney problems may also occur. | Patients with lymphomatoid granulomatosis typically present with nonspecific symptoms such as [[fever]], [[weight loss]], [[cough]], and [[shortness of breath]]. Skin lesions, neurological symptoms, and kidney problems may also occur. | ||
==Diagnosis== | ==Diagnosis== | ||
Diagnosis of lymphomatoid granulomatosis is based on clinical symptoms, imaging studies, and [[biopsy]] of affected tissues. The presence of EBV-infected B cells in the biopsy sample is a key diagnostic feature. | Diagnosis of lymphomatoid granulomatosis is based on clinical symptoms, imaging studies, and [[biopsy]] of affected tissues. The presence of EBV-infected B cells in the biopsy sample is a key diagnostic feature. | ||
==Treatment== | ==Treatment== | ||
Treatment options for lymphomatoid granulomatosis include [[chemotherapy]], [[radiation therapy]], and [[immunotherapy]]. The choice of treatment depends on the severity of the disease and the patient's overall health. | Treatment options for lymphomatoid granulomatosis include [[chemotherapy]], [[radiation therapy]], and [[immunotherapy]]. The choice of treatment depends on the severity of the disease and the patient's overall health. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis of lymphomatoid granulomatosis is variable, with some patients achieving long-term remission while others experience rapid disease progression. | The prognosis of lymphomatoid granulomatosis is variable, with some patients achieving long-term remission while others experience rapid disease progression. | ||
==See Also== | ==See Also== | ||
* [[Lymphoma]] | * [[Lymphoma]] | ||
* [[Epstein-Barr virus]] | * [[Epstein-Barr virus]] | ||
* [[Lymphoproliferative disorders]] | * [[Lymphoproliferative disorders]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Lymphoproliferative disorders]] | [[Category:Lymphoproliferative disorders]] | ||
[[Category:Epstein-Barr virus-associated diseases]] | [[Category:Epstein-Barr virus-associated diseases]] | ||
{{stub}} | {{stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 04:46, 4 April 2025
| Lymphomatoid granulomatosis | |
|---|---|
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Fever, cough, shortness of breath, skin lesions |
| Complications | Pulmonary nodules, central nervous system involvement |
| Onset | |
| Duration | |
| Types | |
| Causes | Epstein-Barr virus infection |
| Risks | Immunosuppression, HIV/AIDS, organ transplantation |
| Diagnosis | Biopsy, imaging studies |
| Differential diagnosis | Wegener's granulomatosis, sarcoidosis, lymphoma |
| Prevention | |
| Treatment | Chemotherapy, immunotherapy, corticosteroids |
| Medication | |
| Prognosis | Variable, depends on stage and response to treatment |
| Frequency | Rare |
| Deaths | N/A |
Lymphomatoid granulomatosis (also known as LYG or LG) is a rare lymphoproliferative disorder characterized by lymphoma-like symptoms. It is associated with Epstein-Barr virus (EBV) infection and is considered a form of angiocentric lymphoma.
Epidemiology[edit]
Lymphomatoid granulomatosis is a rare disease, with an estimated incidence of less than 1 in 1,000,000. It affects both sexes equally and can occur at any age, although it is most common in middle-aged adults.
Pathophysiology[edit]
The disease is characterized by an abnormal proliferation of B cells that are infected with the Epstein-Barr virus. These cells infiltrate the lungs, skin, kidney, central nervous system and other organs, causing inflammation and damage.
Clinical Presentation[edit]
Patients with lymphomatoid granulomatosis typically present with nonspecific symptoms such as fever, weight loss, cough, and shortness of breath. Skin lesions, neurological symptoms, and kidney problems may also occur.
Diagnosis[edit]
Diagnosis of lymphomatoid granulomatosis is based on clinical symptoms, imaging studies, and biopsy of affected tissues. The presence of EBV-infected B cells in the biopsy sample is a key diagnostic feature.
Treatment[edit]
Treatment options for lymphomatoid granulomatosis include chemotherapy, radiation therapy, and immunotherapy. The choice of treatment depends on the severity of the disease and the patient's overall health.
Prognosis[edit]
The prognosis of lymphomatoid granulomatosis is variable, with some patients achieving long-term remission while others experience rapid disease progression.
