Lipodystrophy: Difference between revisions
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{{Infobox medical condition | |||
| name = Lipodystrophy | |||
| synonyms = | |||
| field = [[Endocrinology]], [[Genetics]] | |||
| symptoms = [[Abnormal fat distribution]], [[Insulin resistance]], [[Hypertriglyceridemia]], [[Diabetes mellitus]], [[Hepatic steatosis]] | |||
| complications = [[Cardiovascular disease]], [[Liver disease]], [[Pancreatitis]] | |||
| onset = Varies (congenital or acquired) | |||
| duration = Chronic | |||
| types = [[Congenital generalized lipodystrophy]], [[Acquired partial lipodystrophy]], [[HIV-associated lipodystrophy]] | |||
| causes = Genetic mutations, [[Autoimmune disease]], [[HIV treatment]] | |||
| risks = [[Genetic predisposition]], [[HIV infection]], [[Antiretroviral therapy]] | |||
| diagnosis = [[Clinical examination]], [[Genetic testing]], [[Imaging studies]] | |||
| differential = [[Cushing's syndrome]], [[Metabolic syndrome]], [[Obesity]] | |||
| prevention = Depends on type; genetic counseling for congenital forms | |||
| treatment = [[Dietary management]], [[Metformin]], [[Leptin therapy]], [[Plastic surgery]] | |||
| medication = [[Metformin]], [[Leptin]] | |||
| prognosis = Varies; depends on type and management | |||
| frequency = Rare | |||
}} | |||
'''Lipodystrophy''' is a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. [[Adipose tissue]], or fat, is a crucial part of the body's system, playing a significant role in storing energy and regulating metabolism. Lipodystrophy can be either inherited or acquired. The term lipodystrophy, which literally means abnormal fat, is often used to refer specifically to the syndrome that affects people who are on long-term [[antiretroviral therapy]] (ART) for [[HIV]]. | '''Lipodystrophy''' is a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. [[Adipose tissue]], or fat, is a crucial part of the body's system, playing a significant role in storing energy and regulating metabolism. Lipodystrophy can be either inherited or acquired. The term lipodystrophy, which literally means abnormal fat, is often used to refer specifically to the syndrome that affects people who are on long-term [[antiretroviral therapy]] (ART) for [[HIV]]. | ||
==Types of Lipodystrophy== | ==Types of Lipodystrophy== | ||
There are several types of lipodystrophy, including: | There are several types of lipodystrophy, including: | ||
* '''Congenital generalized lipodystrophy''', also known as Berardinelli-Seip congenital lipodystrophy. This is a rare condition that is present from birth and affects both males and females. | * '''Congenital generalized lipodystrophy''', also known as Berardinelli-Seip congenital lipodystrophy. This is a rare condition that is present from birth and affects both males and females. | ||
* '''Familial partial lipodystrophy''', which affects the limbs and is inherited. | * '''Familial partial lipodystrophy''', which affects the limbs and is inherited. | ||
* '''Acquired partial lipodystrophy''', which is more common in females and usually develops during childhood. | * '''Acquired partial lipodystrophy''', which is more common in females and usually develops during childhood. | ||
* '''HIV-associated lipodystrophy''', which can occur in people who are taking certain antiretroviral medications for HIV. | * '''HIV-associated lipodystrophy''', which can occur in people who are taking certain antiretroviral medications for HIV. | ||
==Symptoms== | ==Symptoms== | ||
The symptoms of lipodystrophy can vary depending on the type and severity of the condition. They can include: | The symptoms of lipodystrophy can vary depending on the type and severity of the condition. They can include: | ||
* Loss of subcutaneous fat | * Loss of subcutaneous fat | ||
* Accumulation of fat in unusual areas, such as the neck and abdomen | * Accumulation of fat in unusual areas, such as the neck and abdomen | ||
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* [[Hepatomegaly]] (enlarged liver) | * [[Hepatomegaly]] (enlarged liver) | ||
* [[Polycystic ovary syndrome]] in women | * [[Polycystic ovary syndrome]] in women | ||
==Treatment== | ==Treatment== | ||
Treatment for lipodystrophy typically involves managing the symptoms and complications of the condition. This can include: | Treatment for lipodystrophy typically involves managing the symptoms and complications of the condition. This can include: | ||
* Dietary changes to manage diabetes and high triglyceride levels | * Dietary changes to manage diabetes and high triglyceride levels | ||
* Medications to reduce insulin resistance and high triglyceride levels | * Medications to reduce insulin resistance and high triglyceride levels | ||
* Plastic surgery to remove excess fat in some cases | * Plastic surgery to remove excess fat in some cases | ||
==See also== | ==See also== | ||
* [[Adipose tissue]] | * [[Adipose tissue]] | ||
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* [[Hepatomegaly]] | * [[Hepatomegaly]] | ||
* [[Polycystic ovary syndrome]] | * [[Polycystic ovary syndrome]] | ||
[[Category:Medical conditions]] | [[Category:Medical conditions]] | ||
[[Category:Endocrine, nutritional and metabolic diseases]] | [[Category:Endocrine, nutritional and metabolic diseases]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{stub}} | {{stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 03:03, 4 April 2025
| Lipodystrophy | |
|---|---|
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Abnormal fat distribution, Insulin resistance, Hypertriglyceridemia, Diabetes mellitus, Hepatic steatosis |
| Complications | Cardiovascular disease, Liver disease, Pancreatitis |
| Onset | Varies (congenital or acquired) |
| Duration | Chronic |
| Types | Congenital generalized lipodystrophy, Acquired partial lipodystrophy, HIV-associated lipodystrophy |
| Causes | Genetic mutations, Autoimmune disease, HIV treatment |
| Risks | Genetic predisposition, HIV infection, Antiretroviral therapy |
| Diagnosis | Clinical examination, Genetic testing, Imaging studies |
| Differential diagnosis | Cushing's syndrome, Metabolic syndrome, Obesity |
| Prevention | Depends on type; genetic counseling for congenital forms |
| Treatment | Dietary management, Metformin, Leptin therapy, Plastic surgery |
| Medication | Metformin, Leptin |
| Prognosis | Varies; depends on type and management |
| Frequency | Rare |
| Deaths | N/A |
Lipodystrophy is a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. Adipose tissue, or fat, is a crucial part of the body's system, playing a significant role in storing energy and regulating metabolism. Lipodystrophy can be either inherited or acquired. The term lipodystrophy, which literally means abnormal fat, is often used to refer specifically to the syndrome that affects people who are on long-term antiretroviral therapy (ART) for HIV.
Types of Lipodystrophy[edit]
There are several types of lipodystrophy, including:
- Congenital generalized lipodystrophy, also known as Berardinelli-Seip congenital lipodystrophy. This is a rare condition that is present from birth and affects both males and females.
- Familial partial lipodystrophy, which affects the limbs and is inherited.
- Acquired partial lipodystrophy, which is more common in females and usually develops during childhood.
- HIV-associated lipodystrophy, which can occur in people who are taking certain antiretroviral medications for HIV.
Symptoms[edit]
The symptoms of lipodystrophy can vary depending on the type and severity of the condition. They can include:
- Loss of subcutaneous fat
- Accumulation of fat in unusual areas, such as the neck and abdomen
- High levels of triglycerides in the blood
- Insulin resistance
- Diabetes
- Hepatomegaly (enlarged liver)
- Polycystic ovary syndrome in women
Treatment[edit]
Treatment for lipodystrophy typically involves managing the symptoms and complications of the condition. This can include:
- Dietary changes to manage diabetes and high triglyceride levels
- Medications to reduce insulin resistance and high triglyceride levels
- Plastic surgery to remove excess fat in some cases
