Mestilbol: Difference between revisions

Latest revision as of 10:55, 23 March 2025

Mestilbol[edit]

Mestilbol is a synthetic anabolic steroid that was developed for medical use but is not currently marketed. It is a derivative of testosterone, the primary male sex hormone and an anabolic steroid. Mestilbol is known for its potential effects on muscle growth and strength, similar to other anabolic steroids.

Chemical Structure and Properties[edit]

Mestilbol is chemically related to testosterone, with modifications that enhance its anabolic properties while reducing its androgenic effects. The chemical structure of Mestilbol includes alterations that make it more resistant to metabolic breakdown, thereby increasing its effectiveness and duration of action in the body.

Mechanism of Action[edit]

Like other anabolic steroids, Mestilbol works by binding to androgen receptors in the body. This binding stimulates protein synthesis, leading to increased muscle mass and strength. The anabolic effects of Mestilbol are primarily due to its ability to enhance nitrogen retention in muscles, which is a key factor in muscle growth.

Medical Uses[edit]

Although Mestilbol was developed for potential medical applications, it is not currently approved for use in any country. The intended medical uses of Mestilbol included treatment of conditions such as muscle wasting and osteoporosis, where increased muscle mass and bone density could be beneficial.

Side Effects[edit]

The use of Mestilbol, like other anabolic steroids, can lead to a range of side effects. These may include:

Androgenic effects such as acne, increased body hair, and voice deepening.
Cardiovascular issues including hypertension and changes in cholesterol levels.
Liver toxicity, particularly with oral formulations.
Endocrine disruption, leading to decreased natural testosterone production.

Legal Status[edit]

Mestilbol is not approved for medical use and is classified as a controlled substance in many countries. Its use is restricted to research purposes, and it is banned in competitive sports by most athletic organizations.

Related Pages[edit]

@@ Line 1: / Line 1: @@
-'''Mestilbol''' is a [[synthetic]], [[steroidal]] [[antiandrogen]] that was never marketed. It is an [[analog]] of [[flutamide]] and was developed in the late 1970s and early 1980s. Mestilbol is related to [[nilutamide]], [[bicalutamide]], and [[enzalutamide]], all of which are nonsteroidal antiandrogens.
+== Mestilbol ==
-==Chemistry==
+[[File:Mestilbol.svg|thumb|right|Chemical structure of Mestilbol]]
-Mestilbol, also known as 17α-methyl-4,5α-dihydrotestosterone, is a synthetic [[androstane]] steroid and a derivative of [[dihydrotestosterone]] (DHT). It is more specifically a derivative of [[metribolone]] (17α-methyl-19-nortestosterone 17β-hydroxy-4,9,11-estratrien-3-one) and is a member of the [[nandrolone]] (19-nortestosterone) and [[mibolerone]] (7α,17α-dimethyl-19-nortestosterone) families.
-==Pharmacology==
+'''Mestilbol''' is a synthetic [[anabolic steroid]] that was developed for medical use but is not currently marketed. It is a derivative of [[testosterone]], the primary male [[sex hormone]] and an [[anabolic steroid]]. Mestilbol is known for its potential effects on muscle growth and strength, similar to other anabolic steroids.
-As an antiandrogen, Mestilbol acts as an [[antagonist]] of the [[androgen receptor]] (AR), the biological target of androgens like [[testosterone]] and DHT. It competes with these androgens for binding to the AR and thereby prevents them from exerting their biological effects in the body. Mestilbol has been found to possess about the same affinity for the AR as metribolone.
-==History==
+== Chemical Structure and Properties ==
-Mestilbol was first described in the literature in 1980 and was developed by the pharmaceutical company [[Roussel Uclaf]] in the late 1970s and early 1980s. However, it was never marketed.
-==See also==
+Mestilbol is chemically related to testosterone, with modifications that enhance its anabolic properties while reducing its androgenic effects. The chemical structure of Mestilbol includes alterations that make it more resistant to metabolic breakdown, thereby increasing its effectiveness and duration of action in the body.
-* [[List of androgen receptor antagonists]]
-* [[List of steroidal antiandrogens]]
-[[Category:Androgens and anabolic steroids]]
+== Mechanism of Action ==
-[[Category:Antiandrogens]]
-[[Category:Androgen receptor antagonists]]
+Like other anabolic steroids, Mestilbol works by binding to [[androgen receptors]] in the body. This binding stimulates protein synthesis, leading to increased muscle mass and strength. The anabolic effects of Mestilbol are primarily due to its ability to enhance nitrogen retention in muscles, which is a key factor in muscle growth.
-[[Category:Abandoned drugs]]
-[[Category:Pharmaceuticals]]
+== Medical Uses ==
-{{Pharma-stub}}
-<gallery>
+Although Mestilbol was developed for potential medical applications, it is not currently approved for use in any country. The intended medical uses of Mestilbol included treatment of conditions such as [[muscle wasting]] and [[osteoporosis]], where increased muscle mass and bone density could be beneficial.
-File:Mestilbol.svg|Mestilbol
-</gallery>
+== Side Effects ==
-<gallery>
-File:Mestilbol.svg|Mestilbol
+The use of Mestilbol, like other anabolic steroids, can lead to a range of side effects. These may include:
-</gallery>
+* [[Androgenic effects]] such as acne, increased body hair, and voice deepening.
+* [[Cardiovascular issues]] including hypertension and changes in cholesterol levels.
+* [[Liver toxicity]], particularly with oral formulations.
+* [[Endocrine disruption]], leading to decreased natural testosterone production.
+== Legal Status ==
+Mestilbol is not approved for medical use and is classified as a controlled substance in many countries. Its use is restricted to research purposes, and it is banned in competitive sports by most athletic organizations.
+== Related Pages ==
+* [[Anabolic steroid]]
+* [[Testosterone]]
+* [[Androgen receptor]]
+* [[Muscle hypertrophy]]
+[[Category:Anabolic steroids]]