Pancreatic polypeptide receptor 1

Pancreatic polypeptide receptor 1 (PPR1), also known as Neuropeptide Y receptor type 4 (NPY4R), is a protein that in humans is encoded by the NPY4R gene. This receptor is a member of the neuropeptide Y receptors family, which are G protein-coupled receptors involved in various biological processes.

Function

PPR1 is a receptor for pancreatic polypeptide (PP), a hormone secreted by the pancreas. PP is involved in the regulation of pancreatic secretion, gastrointestinal motility, and energy metabolism. The binding of PP to PPR1 triggers a series of intracellular events, including the activation of adenylate cyclase and phospholipase C, leading to changes in cAMP levels and calcium influx.

Clinical significance

Alterations in the function of PPR1 have been associated with various diseases. For example, mutations in the NPY4R gene have been linked to obesity and type 2 diabetes. In addition, PPR1 has been implicated in the regulation of appetite and food intake, making it a potential target for the treatment of eating disorders and obesity.

See also

• Neuropeptide Y receptor
• Pancreatic polypeptide
• G protein-coupled receptor
• Obesity
• Type 2 diabetes

References

This GPCR-related article is a stub. You can help WikiMD by expanding it.

   This article is a protein-related stub. You can help WikiMD by expanding it!