Paraneoplastic keratoderma

Paraneoplastic keratoderma is a rare skin condition that is associated with internal malignancies. It is characterized by the thickening and hardening of the skin, particularly on the palms of the hands and soles of the feet. This condition is often a sign of an underlying cancer, most commonly lung cancer, but also other types such as breast cancer, gastrointestinal cancer, and lymphoma.

Symptoms

The main symptom of paraneoplastic keratoderma is the thickening and hardening of the skin on the palms and soles. This can cause discomfort and difficulty walking or using the hands. Other symptoms can include changes in skin color, itching, and the development of skin lesions.

Causes

Paraneoplastic keratoderma is caused by the body's immune response to an underlying cancer. The exact mechanism is not fully understood, but it is thought that the cancer cells produce substances that stimulate the growth of skin cells, leading to the thickening and hardening of the skin.

Diagnosis

The diagnosis of paraneoplastic keratoderma is usually made based on the characteristic skin changes and the presence of an underlying cancer. Skin biopsy may be performed to confirm the diagnosis. Other tests, such as blood tests and imaging studies, may be done to identify the underlying cancer.

Treatment

The treatment of paraneoplastic keratoderma involves treating the underlying cancer. This can involve surgery, chemotherapy, radiation therapy, or a combination of these. In some cases, the skin changes may improve or resolve once the cancer is treated. Topical treatments, such as creams and ointments, may also be used to help manage the skin symptoms.

See also

• Keratoderma
• Paraneoplastic syndromes
• Lung cancer
• Breast cancer
• Gastrointestinal cancer
• Lymphoma

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