TICAM1

TICAM1 (also known as TRIF) is a protein that in humans is encoded by the TICAM1 gene. It is a part of the Toll-like receptor (TLR) signaling pathway, which plays a crucial role in innate immunity and inflammation.

Function

TICAM1 is an adaptor protein in the Toll-like receptor (TLR) signaling pathway. It is involved in the production of interferons and proinflammatory cytokines in response to the activation of TLRs. TICAM1 is essential for the induction of Type I interferons that are important in the innate immune response.

Clinical significance

Mutations in the TICAM1 gene have been associated with herpes simplex encephalitis, a rare complication of herpes simplex virus infection. This suggests that TICAM1 plays a role in the immune response to this virus.

See also

• Toll-like receptor
• Interferon
• Cytokine
• Herpes simplex virus
• Herpes simplex encephalitis

References

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External links

• NCBI Gene
• UniProt

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