ARID4A

ARID4A (AT-rich interaction domain 4A) is a protein that in humans is encoded by the ARID4A gene. This protein is a key component of the histone deacetylase complex, which plays a crucial role in the regulation of gene expression.

Function

The ARID4A protein is part of the mSin3A family of histone deacetylase complexes, which are involved in the transcriptional repression of genes. This protein contains two AT-rich interaction domains (ARID), which are responsible for binding to AT-rich regions of DNA. The ARID4A protein also contains a chromodomain, which is involved in the recognition of histone modifications.

Clinical significance

Mutations in the ARID4A gene have been associated with various types of cancer, including breast cancer and ovarian cancer. The ARID4A protein is thought to act as a tumor suppressor, and loss of its function can lead to uncontrolled cell growth and tumorigenesis.

Research

Research into the role of ARID4A in cancer is ongoing, with studies investigating its potential as a biomarker for cancer diagnosis and prognosis, as well as a target for cancer therapy.

See also

• AT-rich interaction domain
• Histone deacetylase
• Gene expression
• Transcriptional repression
• Cancer

References

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