Carbazide: Difference between revisions

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'''Carbazide''' refers to a chemical compound that consists of a hydrazine group (-NH-NH-) attached to two carbonyl groups (-C(=O)-). It is an organic compound with the formula OC(NH-NH)2. Carbazides are used in various chemical reactions, particularly in the synthesis of pharmaceuticals, agrochemicals, and dyes. They are known for their role in the formation of heterocyclic compounds, which are crucial in the development of various therapeutic agents.
{{Short description|Chemical compound}}
{{Chembox
| ImageFile = Carbazide.png
| ImageSize = 200px
| ImageAlt = Structural formula of carbazide
| IUPACName = Carbonohydrazide
| OtherNames = Carbazic acid hydrazide
| Section1 = {{Chembox Identifiers
  | CASNo = 497-18-7
  | PubChem = 10478
  | ChemSpiderID = 10042
  | UNII = 8D8Q1VIX9U
  | SMILES = NNC(=O)NN
  | InChI = 1S/CH6N4O/c2-1(6)5-3-4/h3-4H2,(H2,2,5,6)
  | InChIKey = ZFSLODLOARCGLH-UHFFFAOYSA-N
}}
}}


==Properties and Synthesis==
'''Carbazide''', also known as '''carbonohydrazide''', is a chemical compound with the formula CH_N_O. It is a derivative of [[hydrazine]] and is used in various chemical applications, including as a reagent in organic synthesis and as a stabilizer in the production of [[explosives]].
Carbazides are characterized by their solid state at room temperature and their ability to act as intermediates in the synthesis of other chemical compounds. The synthesis of carbazides typically involves the reaction of hydrazine with urea or diisocyanates. This process can lead to the formation of a wide range of carbazide derivatives, depending on the reactants and conditions employed.
 
==Structure and Properties==
Carbazide is a white crystalline solid at room temperature. It is soluble in water and has a melting point of approximately 153°C. The compound consists of a carbonyl group (C=O) bonded to two hydrazine groups (NH-NH_), making it a member of the [[hydrazide]] family.
 
[[File:Carbazide-3D-balls.png|thumb|left|3D model of carbazide molecule]]
 
The molecular structure of carbazide allows it to act as a versatile intermediate in chemical reactions, particularly in the formation of [[heterocyclic compounds]]. Its ability to form stable complexes with metal ions makes it useful in coordination chemistry.


==Applications==
==Applications==
The applications of carbazides are diverse, owing to their reactivity and ability to form complex molecules. In the pharmaceutical industry, carbazides are used in the synthesis of various drugs, including antituberculosis agents, antiviral drugs, and anticancer compounds. In agrochemicals, carbazide derivatives serve as precursors for the synthesis of herbicides and insecticides. Additionally, carbazides are employed in the production of dyes and pigments, where they contribute to the formation of azo and azomethine compounds.
Carbazide is primarily used in the following applications:


==Safety and Environmental Considerations==
===Organic Synthesis===
The handling of carbazides requires caution due to their potential reactivity and toxicity. Proper safety measures, including the use of personal protective equipment (PPE) and adequate ventilation, are essential to minimize exposure risks. Environmental considerations are also important, as the disposal of carbazide-containing waste must be managed in accordance with local regulations to prevent environmental contamination.
In organic chemistry, carbazide is employed as a reagent for the synthesis of various [[heterocyclic compounds]]. It can react with [[aldehydes]] and [[ketones]] to form hydrazones, which are important intermediates in the synthesis of pharmaceuticals and agrochemicals.


==See Also==
===Explosives Stabilization===
Carbazide is used as a stabilizer in the production of [[explosives]]. It helps to prevent the decomposition of explosive materials, thereby enhancing their shelf life and safety during storage and handling.
 
===Analytical Chemistry===
In analytical chemistry, carbazide is used as a reagent for the detection of certain metal ions. It forms colored complexes with metals such as [[copper]] and [[iron]], which can be used for quantitative analysis.
 
==Safety and Handling==
Carbazide should be handled with care, as it can be hazardous if ingested or inhaled. It is recommended to use appropriate personal protective equipment, such as gloves and goggles, when working with this compound. In case of contact with skin or eyes, the affected area should be rinsed thoroughly with water.
 
==Related Pages==
* [[Hydrazine]]
* [[Hydrazine]]
* [[Urea]]
* [[Diisocyanate]]
* [[Heterocyclic compound]]
* [[Heterocyclic compound]]
* [[Pharmaceutical industry]]
* [[Explosive material]]
* [[Agrochemical]]
* [[Coordination chemistry]]
* [[Dye]]
 
[[Category:Organic compounds]]
[[Category:Chemical compounds]]
[[Category:Pharmaceutical chemistry]]


{{Chemistry-stub}}
[[Category:Hydrazides]]
<gallery>
[[Category:Explosive chemicals]]
File:Carbazide.png|Carbazide
[[Category:Reagents for organic chemistry]]
File:Carbohydrazide.png|Carbohydrazide
File:Diphenylcarbazide.svg|Diphenylcarbazide
</gallery>

Revision as of 17:31, 18 February 2025

Chemical compound


Chemical Compound
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PubChem CID
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ChEMBL
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References

Carbazide, also known as carbonohydrazide, is a chemical compound with the formula CH_N_O. It is a derivative of hydrazine and is used in various chemical applications, including as a reagent in organic synthesis and as a stabilizer in the production of explosives.

Structure and Properties

Carbazide is a white crystalline solid at room temperature. It is soluble in water and has a melting point of approximately 153°C. The compound consists of a carbonyl group (C=O) bonded to two hydrazine groups (NH-NH_), making it a member of the hydrazide family.

File:Carbazide-3D-balls.png
3D model of carbazide molecule

The molecular structure of carbazide allows it to act as a versatile intermediate in chemical reactions, particularly in the formation of heterocyclic compounds. Its ability to form stable complexes with metal ions makes it useful in coordination chemistry.

Applications

Carbazide is primarily used in the following applications:

Organic Synthesis

In organic chemistry, carbazide is employed as a reagent for the synthesis of various heterocyclic compounds. It can react with aldehydes and ketones to form hydrazones, which are important intermediates in the synthesis of pharmaceuticals and agrochemicals.

Explosives Stabilization

Carbazide is used as a stabilizer in the production of explosives. It helps to prevent the decomposition of explosive materials, thereby enhancing their shelf life and safety during storage and handling.

Analytical Chemistry

In analytical chemistry, carbazide is used as a reagent for the detection of certain metal ions. It forms colored complexes with metals such as copper and iron, which can be used for quantitative analysis.

Safety and Handling

Carbazide should be handled with care, as it can be hazardous if ingested or inhaled. It is recommended to use appropriate personal protective equipment, such as gloves and goggles, when working with this compound. In case of contact with skin or eyes, the affected area should be rinsed thoroughly with water.

Related Pages