Marginal zone lymphoma

Marginal zone lymphoma (MZL) is a type of Non-Hodgkin lymphoma that affects B cells. It is named for the marginal zone of the lymph node where these cells are found. MZL is a slow-growing, or indolent, lymphoma. There are three types of MZL: extranodal MZL of mucosa-associated lymphoid tissue (MALT), nodal MZL, and splenic MZL.

Types

Extranodal MZL of MALT

Extranodal marginal zone B cell lymphoma or MALT lymphoma, is the most common type of MZL. It can occur in various parts of the body, including the stomach, lungs, eyes, and skin.

Nodal MZL

Nodal marginal zone B cell lymphoma is a rare type of MZL that occurs in the lymph nodes.

Splenic MZL

Splenic marginal zone lymphoma affects the spleen and the blood. It can also affect the bone marrow.

Symptoms

Symptoms of MZL can vary depending on the type and location of the lymphoma. They may include swelling of the lymph nodes, stomach pain, fatigue, and weight loss.

Diagnosis

Diagnosis of MZL typically involves a biopsy of the affected tissue. Other tests may include blood tests, imaging tests, and a bone marrow biopsy.

Treatment

Treatment for MZL depends on the type and stage of the lymphoma, as well as the patient's overall health. Options may include watchful waiting, radiation therapy, chemotherapy, immunotherapy, and in some cases, surgery.

Prognosis

The prognosis for MZL is generally good, with many patients living for many years after diagnosis. However, the disease is often not curable and may require ongoing treatment.

See also

• Lymphoma
• Non-Hodgkin lymphoma
• B cells
• Lymph node

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