Desmethylcitalopram

Desmethylcitalopram is a metabolite of the antidepressant drug citalopram, which is commonly used in the treatment of depression and anxiety disorders. It is produced in the body during the metabolism of citalopram, and has been found to have antidepressant activity in its own right.

Pharmacology

Desmethylcitalopram is a selective serotonin reuptake inhibitor (SSRI), like its parent drug citalopram. This means it works by increasing the levels of serotonin in the brain, which helps to improve mood and reduce feelings of anxiety.

Clinical Use

While desmethylcitalopram is not used directly as a medication, it is an important part of the overall effect of citalopram. The levels of desmethylcitalopram in the body can be affected by factors such as age, liver function, and the use of other medications, which can influence the effectiveness of citalopram treatment.

Side Effects

As a metabolite of citalopram, desmethylcitalopram can contribute to the side effects of this medication. These can include nausea, insomnia, dry mouth, and sexual dysfunction. In rare cases, it can also contribute to more serious side effects such as serotonin syndrome.

See Also

• Citalopram
• Selective serotonin reuptake inhibitor
• Serotonin syndrome

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