* CYP4F2 is a member of the [[Cytochrome P450 enzyme system|cytochrome P450 enzyme]] family involved in the metabolism of various endogenous compounds and exogenous substances.
== Overview ==
* This enzyme is primarily expressed in the liver and is encoded by the CYP4F2 gene.
'''CYP4F2''' is a member of the [[cytochrome P450]] superfamily of enzymes. These enzymes are involved in the metabolism of various substances within the body, including drugs and endogenous compounds. CYP4F2 is specifically known for its role in the hydroxylation of [[leukotriene B4]], a process that is crucial for the regulation of inflammatory responses.
* CYP4F2 plays a role in the metabolism of [[fatty acids]], [[eicosanoids]], and [[xenobiotics]].
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== Function ==
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CYP4F2 is primarily expressed in the [[liver]] and [[kidney]], where it participates in the metabolism of fatty acids and eicosanoids. One of its key functions is the omega-hydroxylation of leukotriene B4, converting it into 20-hydroxy-leukotriene B4, which is less active and more easily excreted from the body.
[[File:Leukotriene_B4_hydroxylation_traced.svg|thumb|right|300px|Diagram of leukotriene B4 hydroxylation by CYP4F2.]]
* The main functions of CYP4F2 include:
== Clinical Significance ==
CYP4F2 has been implicated in the metabolism of [[vitamin E]] and [[arachidonic acid]]. Variations in the CYP4F2 gene can affect the enzyme's activity, influencing an individual's response to certain medications, such as [[warfarin]], and susceptibility to diseases related to inflammation and oxidative stress.
'''Fatty Acid Metabolism:'''
== Genetic Variability ==
* CYP4F2 participates in the metabolism of long-chain fatty acids, including omega-3 and omega-6 fatty acids.
The CYP4F2 gene is located on chromosome 19 and exhibits genetic polymorphisms that can lead to variations in enzyme activity. One well-studied polymorphism is the V433M variant, which has been associated with altered warfarin dose requirements in patients.
* It is involved in the oxidation of these fatty acids, contributing to their breakdown and subsequent elimination from the body.
'''Eicosanoid Metabolism:'''
== Related Enzymes ==
* Eicosanoids are signaling molecules derived from [[arachidonic acid]] and play important roles in inflammation and blood clotting.
CYP4F2 is part of the CYP4F subfamily, which includes other enzymes such as [[CYP4F3]] and [[CYP4F11]]. These enzymes share similar functions but differ in their tissue distribution and substrate specificity.
* CYP4F2 contributes to the metabolism of certain [[eicosanoids]], such as [[leukotrienes]] and [[prostaglandins]], through oxidation reactions.
* This metabolism helps regulate the levels and activities of these signaling molecules in the body.
'''Xenobiotic Metabolism:'''
== Related Pages ==
* CYP4F2 participates in the metabolism of various [[xenobiotics]], including drugs and environmental chemicals.
* [[Cytochrome P450]]
* It can metabolize certain medications and xenobiotics through oxidation reactions, leading to their inactivation or conversion into more polar forms for elimination.
* [[Leukotriene B4]]
* [[Warfarin]]
== '''Genetic Variations'''==
* [[Vitamin E]]
* Genetic variations in the CYP4F2 gene can influence enzyme activity and individual responses to certain medications.
* Some notable genetic variants include:
'''CYP4F2*3 (rs2108622):'''
* This variant is associated with reduced enzyme activity compared to the wild-type allele.
* Individuals carrying the CYP4F2*3 variant may exhibit altered drug metabolism and responses to certain medications.
== '''Clinical Significance''' ==
* The CYP4F2*3 variant has been particularly studied in relation to its impact on medication response, including:
* Warfarin: CYP4F2 is involved in the metabolism of [[warfarin]], an anticoagulant medication. Individuals carrying the CYP4F2*3 variant may exhibit altered warfarin metabolism, potentially requiring adjusted dosage regimens and closer monitoring of anticoagulation levels.
* It's important to note that the impact of CYP4F2 genetic variations on drug metabolism and therapeutic outcomes may vary depending on the specific medication, other genetic factors, and individual patient characteristics. Pharmacogenetic testing may be considered in certain clinical scenarios to guide personalized medication selection and dosing.
== '''Alternate Names:'''==
* CYP4F2, also known as Cytochrome P450 4F2, is an enzyme encoded by the CYP4F2 gene.
While it is primarily recognized by its official name, CYP4F2, this gene and its corresponding enzyme are known by other names as well:
* '''Leukotriene B4 omega-hydroxylase:''' CYP4F2 gained attention as the primary enzyme responsible for the omega-hydroxylation of [[leukotriene B4]], an important [[eicosanoid]] involved in [[inflammation]] and immune responses.
* '''Lipoxin A4 omega-hydroxylase:''' CYP4F2 also participates in the omega-hydroxylation of [[lipoxin A4]], a specialized pro-resolving mediator derived from [[arachidonic acid]] that plays a role in the resolution of [[inflammation]].
* '''Arachidonic acid monooxygenase:''' CYP4F2 is involved in the oxidation of [[arachidonic acid]], a polyunsaturated fatty acid that serves as a precursor for various [[eicosanoids]].
* These alternative names may be encountered in scientific literature or discussions related to CYP4F2.
CYP4F2 is a member of the cytochrome P450 superfamily of enzymes. These enzymes are involved in the metabolism of various substances within the body, including drugs and endogenous compounds. CYP4F2 is specifically known for its role in the hydroxylation of leukotriene B4, a process that is crucial for the regulation of inflammatory responses.
CYP4F2 is primarily expressed in the liver and kidney, where it participates in the metabolism of fatty acids and eicosanoids. One of its key functions is the omega-hydroxylation of leukotriene B4, converting it into 20-hydroxy-leukotriene B4, which is less active and more easily excreted from the body.
CYP4F2 has been implicated in the metabolism of vitamin E and arachidonic acid. Variations in the CYP4F2 gene can affect the enzyme's activity, influencing an individual's response to certain medications, such as warfarin, and susceptibility to diseases related to inflammation and oxidative stress.
The CYP4F2 gene is located on chromosome 19 and exhibits genetic polymorphisms that can lead to variations in enzyme activity. One well-studied polymorphism is the V433M variant, which has been associated with altered warfarin dose requirements in patients.
CYP4F2 is part of the CYP4F subfamily, which includes other enzymes such as CYP4F3 and CYP4F11. These enzymes share similar functions but differ in their tissue distribution and substrate specificity.
